XIAP Antibody

Western Blot: XIAP Antibody [NB600-872] - Analysis of XIAP expression in Jurkat cell lysate.

Product Discontinued

XIAP Antibody Summary

• Description: This product is manufactured by Abcam and distributed by Novus Biologicals. (Abcam Catalog Number: ab2541)
• Immunogen: Synthetic peptide surrounding amino acid 230 of human XIAP (ID# BV-94)
• Specificity: This detects the 53 kDa human XIAP protein. It does not cross-react with other apoptosis inhibitors.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: XIAP
• Purity: Affinity purified

Applications/Dilutions

• Dilutions:
  • Western Blot 0.5 - 4 ug/mL
• Theoretical MW: 57 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
• Control:

  XIAP Overexpression Lysate

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.2), 0.5% BSA, 30% Glycerol
• Preservative: 0.01% Thimerosal
• Concentration: 0.2 mg/ml
• Purity: Affinity purified

Alternate Names for XIAP Antibody

• API3X-linked inhibitor of apoptosis protein
• apoptosis inhibitor 3
• baculoviral IAP repeat-containing 4
• baculoviral IAP repeat-containing protein 4
• BIRC4
• BIRC4XLP2
• E3 ubiquitin-protein ligase XIAP
• EC 6.3.2.-
• hIAP3
• hIAP-3
• hILP
• IAP3
• IAP-3
• IAP-like protein
• ILP
• ILP1
• Inhibitor of apoptosis protein 3
• MIHA
• XIAP
• X-linked IAP
• X-linked inhibitor of apoptosis

Background

The human X-chromosome-linked inhibitor of apoptosis protein (XIAP) is a major member of the inhibitor of apoptosis (IAP) family. XIAP functions by direct binding and inhibition of several caspases, including caspase-3, caspase-7 and caspase-9. During apoptosis XIAP is specifically cleaved by caspase-3 and partially loses its function. In addition to blocking the apoptosis signaling pathway, XIAP can also bind several other proteins in the bone morphogenetic protein (BMP) signaling pathway and act as a coupler between the membrane BMP receptor and the TAB1-TAK1 complex by binding to these proteins.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause reproductive toxicity with developmental effects.  For more information go to www.P65Warnings.ca.gov.

Review for XIAP Antibody (NB600-872) (1)

Average Rating: 2

(Based on 1 review)

We have 1 review tested in 1 species: Mouse.

reviewed by: Verified Customer WB Mouse 11/13/2019

Summary

• Application: Western Blot
• Sample Tested: neonatal cardiac myocytes
• Species: Mouse
• Lot: 50783

Bioinformatics

• Gene Symbol: XIAP
• Entrez:
  • 331(Human)
  • 11798(Mouse)
  • 63879(Rat)
• Uniprot:
  • P98170()