Hu, Mu, RtApplications:
WB, Simple Western, IHCHost:
Hu, Mu, RtApplications:
WB, IHC, IHC-P, IPHost:
Applications: WB, IP
Applications: WB, ELISA, PA
XIAP [human X-linked IAP, hILP (human IAP-like protein), MIHA, BIRC4) is a member of the family of inhibitor of apoptosis proteins (IAP). IAPs suppress mitochondria-dependent and independent apoptosis by binding to and inhibiting caspases through their BIR domains (reviewed in Liston et al, 2003; Wright and Duckett, 2005). Resistance towards apoptosis is a hallmark of cancer cells, and overexpression of IAPs can contribute to the development of cancer though inhibiting apoptosis. In addition to at least one BIR domain, some IAP members also have a RING-type finger motif at their carboxyl-terminal. The RING finger domain of several IAPs, including XIAP, have E3 ubiquitin ligase activity and target the degradation of Smac/DIABLO through ubqiuitination (Morizane et al, 2005). Smac/DIABLO is a death inducer and functions by inhibiting IAP-caspase interactions, thereby promoting apoptosis. Degradation of cell death inducers like Smac/DIABLO is thought to be a conserved mechanism by which IAPs enhance their anti-apoptotic activity, thereby promoting cell survival. XIAP is highly characterized with respect to its structure and biochemical mechanisms, and has received interest as a therapeutic target (reviewed in Schimmer, 2006). Since XIAP blocks a substantial portion of the apoptosis pathway and is associated with chemoresistance in cancer cells, inhibiting XIAP has been a focus for potential therapeutics. Approaches have included antisense oligonucleotides and small molecule inhibitors. Small molecules that that target the BIR2 and BIR3 domains of XIAP are considered particularly attractive. This is because the BIR domains inhibit caspase activity, and it is thought that removing the inhibition should increase the cell's ability to undergo apoptosis as well as decrease its potential for chemoresistance. Full-length human XIAP is a 497 amino acid protein and migrates at approx. 53 kDa on SDS-PAGE.
|Product By Gene ID
- IAP-like protein
- EC 6.3.2.-
- E3 ubiquitin-protein ligase XIAP
- baculoviral IAP repeat-containing protein 4
- apoptosis inhibitor 3
- Inhibitor of apoptosis protein 3
- baculoviral IAP repeat-containing 4
- API3X-linked inhibitor of apoptosis protein
- X-linked IAP
- X-linked inhibitor of apoptosis
Research Areas for XIAP
Find related products by research area and learn more about each of the different research areas below.ApoptosisCancer
Bioinformatics Tool for XIAP
Discover related pathways, diseases and genes to XIAP. Need help? Read the Bioinformatics Tool Guide
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Related XIAP Blog Posts
Check out the latest blog posts on XIAP.
Read more XIAP related blogs.
|Caspase 9 - an important apoptosis marker
Caspases are essential mediators of programmed cell death and are needed for both the induction of apoptosis as well as for aiding the degradation of cellular structures. Initiator caspases (such as Caspase-9) sense and respond to various signals i... Read more.
|cIAP2 - balancing cell death and cell survival
The inhibitor of apoptosis proteins (IAPs) are important regulators of cell death and inflammation. The cellular inhibitor of apoptosis protein 2 (cIAP2) contains three Baculovirus IAP repeat (BIR) domains, a Ubiquitin associated (UBA) domain, and... Read more.