XIAP Products

Antibodies
XIAP Antibody [Unconjugated]
XIAP Antibody [Unconjugated]
Species: Hu, Mu, Rt
Applications: WB, Simple Western, IHC, KO
Host: Goat Polyclonal
Conjugate Catalog # Availability Size Price
Formulation Catalog # Availability Price  
XIAP Antibody
XIAP Antibody
NB100-56183
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC, IP
Host: Rabbit Polyclonal
XIAP Antibody (117320) [Uncon ...
XIAP Antibody (117320) [Unconjugated]
Species: Hu, Mu
Applications: WB, KO
Host: Mouse Monoclonal
Formulation Catalog # Availability Price  
ELISA Kits
Human Total XIAP DuoSet IC EL ...
Human Total XIAP DuoSet IC ELISA, ...
DYC822-2
Species: Hu
Applications: ELISA
Conjugate Catalog # Availability Size Price
Lysates
XIAP Overexpression Lysate
XIAP Overexpression Lysate
NBL1-17905
Species: Hu
Applications: WB
Proteins
Recombinant Human XIAP (Full ...
Recombinant Human XIAP (Full Lengt...
822-XF
Species: Hu
Applications: Inhibition Activity
Formulation Catalog # Availability Price  
Recombinant Human XIAP (BIR3) ...
Recombinant Human XIAP (BIR3) Prot...
895-XB
Species: Hu
Applications: Inhibition Activity
Formulation Catalog # Availability Price  
Recombinant Human XIAP Wester ...
Recombinant Human XIAP Western Blo...
WBC002
Species: Hu
Applications: WB

Description

XIAP [human X-linked IAP, hILP (human IAP-like protein), MIHA, BIRC4) is a member of the family of inhibitor of apoptosis proteins (IAP). IAPs suppress mitochondria-dependent and independent apoptosis by binding to and inhibiting caspases through their BIR domains (reviewed in Liston et al, 2003; Wright and Duckett, 2005). Resistance towards apoptosis is a hallmark of cancer cells, and overexpression of IAPs can contribute to the development of cancer though inhibiting apoptosis. In addition to at least one BIR domain, some IAP members also have a RING-type finger motif at their carboxyl-terminal. The RING finger domain of several IAPs, including XIAP, have E3 ubiquitin ligase activity and target the degradation of Smac/DIABLO through ubqiuitination (Morizane et al, 2005). Smac/DIABLO is a death inducer and functions by inhibiting IAP-caspase interactions, thereby promoting apoptosis. Degradation of cell death inducers like Smac/DIABLO is thought to be a conserved mechanism by which IAPs enhance their anti-apoptotic activity, thereby promoting cell survival. XIAP is highly characterized with respect to its structure and biochemical mechanisms, and has received interest as a therapeutic target (reviewed in Schimmer, 2006). Since XIAP blocks a substantial portion of the apoptosis pathway and is associated with chemoresistance in cancer cells, inhibiting XIAP has been a focus for potential therapeutics. Approaches have included antisense oligonucleotides and small molecule inhibitors. Small molecules that that target the BIR2 and BIR3 domains of XIAP are considered particularly attractive. This is because the BIR domains inhibit caspase activity, and it is thought that removing the inhibition should increase the cell's ability to undergo apoptosis as well as decrease its potential for chemoresistance. Full-length human XIAP is a 497 amino acid protein and migrates at approx. 53 kDa on SDS-PAGE.

Bioinformatics

Entrez Mouse
Human
Rat
Uniprot Human
Human
Human
Human
Human
Alternate Names
  • API3X-linked inhibitor of apoptosis protein
  • apoptosis inhibitor 3
  • baculoviral IAP repeat-containing 4
  • baculoviral IAP repeat-containing protein 4
  • BIRC4XLP2
  • E3 ubiquitin-protein ligase XIAP
  • EC 6.3.2.-
  • hIAP3
  • hIAP-3
  • hILP
  • IAP3
  • IAP-3
  • IAP-like protein
  • ILP
  • ILP1
  • Inhibitor of apoptosis protein 3
  • MIHA
  • X-linked IAP
  • X-linked inhibitor of apoptosis

Research Areas for XIAP

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cancer