XCL1/Lymphotactin Antibody (109001) [Alexa Fluor® 647]

• Reactivity: Hu
• Applications: WB, ELISA(Cap), ELISA(Det)
• Clone: 109001
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 647

XCL1/Lymphotactin Antibody (109001) [Alexa Fluor® 647] Summary

• Immunogen: E. coli-derived recombinant human XCL1/Lymphotactin
  Val22-Gly114
  Accession # P47992
• Specificity: Detects human XCL1/Lymphotactin in ELISAs and Western blots. In sandwich ELISAs, less than 0.15% cross-reactivity was observed with recombinant mouse MCP‑5, recombinant human (rh) MIP‑3 beta , rhGRO alpha , rhTGF‑ alpha , rhGRO gamma , rhActivin RII Fc Chimera, rhIGF‑
• Source: N/A
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified from ascites

Applications/Dilutions

• Dilutions:
  • ELISA Capture (Matched Antibody Pair)
  • ELISA Detection (Matched Antibody Pair)
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is provided under an agreement between Life Technologies Corporation and R&D Systems, Inc, and the manufacture, use, sale or import of this product is subject to one or more US patents and corresponding non-US equivalents, owned by Life Technologies Corporation and its affiliates. The purchase of this product conveys to the buyer the non-transferable right to use the purchased amount of the product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components (1) in manufacturing; (2) to provide a service, information, or data to an unaffiliated third party for payment; (3) for therapeutic, diagnostic or prophylactic purposes; (4) to resell, sell, or otherwise transfer this product or its components to any third party, or for any other commercial purpose. Life Technologies Corporation will not assert a claim against the buyer of the infringement of the above patents based on the manufacture, use or sale of a commercial product developed in research by the buyer in which this product or its components was employed, provided that neither this product nor any of its components was used in the manufacture of such product. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, Cell Analysis Business Unit, Business Development, 29851 Willow Creek Road, Eugene, OR 97402, Tel: (541) 465-8300. Fax: (541) 335-0354.

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for XCL1/Lymphotactin Antibody (109001) [Alexa Fluor® 647]

• ATAC
• ATACSmall-inducible cytokine C1
• C motif chemokine 1
• chemokine (C motif) ligand 1
• Cytokine SCM-1
• LPTNSCM-1-alpha
• LTNXC chemokine ligand 1
• Lymphotactin
• lymphotaxin
• SCM-1 alpha
• SCM-1
• SCM1A
• SCM-1a
• SCYC1SCM1
• single cysteine motif 1a
• small inducible cytokine subfamily C, member 1 (lymphotactin)
• XCL1

Background

Human lymphotactin (Lptn)/XCL1 (also named human SCM-1 alpha and ATAC) and its mouse homologue belong to the C or gamma  subfamily of chemokines. The C chemokines lack two (the 1st and 3rd ) of the four invariant cysteine residues normally found in the CC and CXC chemokines and have an extended carboxy terminus. Human lymphotactin encodes a 114 amino acid residue precursor protein with a 21 amino acid residue predicted signal peptide. The expression of lymphotactin is abundant in some activated T cells such as activated CD8⁺ T cells and other class I MHC restricted T cells. Lptn expression is absent in CD4⁺ T cells. Human and mouse Lptn share approximately 60% amino acid sequence homology. The gene for lymphotactin has been mapped to chromosome 1 in both human and mouse. Recombinant human lymphotactin has been shown to have chemotactic activity for lymphocytes and NK cells. The orphan receptor GPR5 has been reported to be the specific receptor for Lptn.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Uniprot:
  • P47992()