Recombinant Human WWOX Protein

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SDS-Page: WWOX Protein [NBC1-28766] - WWOX, 28.3 kDa (254aa), confirmed by MALDI-TOF with a purity of 85% by SDS - PAGE

Product Details

Summary
Reactivity HuSpecies Glossary
Applications PAGE
Concentration
1 mg/ml

Order Details

Recombinant Human WWOX Protein Summary

Description
A recombinant protein with a N-Terminal His-tag and corresponding to the amino acids 1-234 of Human WWOX

Source: E.coli

Amino Acid Sequence: MGSSHHHHHH SSGLVPRGSH MAALRYAGLD DTDSEDELPP GWEERTTKDG WVYYANHTEE KTQWEHPKTG KRKRVAGDLP YGWEQETDEN GQVFFVDHIN KRTTYLDPRL AFTVDDNPTK PTTRQRYDGS TTAMEILQGR DFTGKVVVVT GANSGIGFET AKSFALHGAH VILACRNMAR ASEAVSRILE EWQQGAATTV YCAAVPELEG LGGMYFNNCC RCMPSPEAQS EETARTLWAL SERLIQERLG SQSG

Source
E. coli
Protein/Peptide Type
Recombinant Protein
Gene
WWOX
Purity
>85%, by SDS-PAGE

Applications/Dilutions

Theoretical MW
28.3 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol
Preservative
No Preservative
Concentration
1 mg/ml
Purity
>85%, by SDS-PAGE

Alternate Names for Recombinant Human WWOX Protein

  • D16S432E
  • EC 1.1.1
  • EC 1.1.1.-
  • FOR
  • FORHHCMA56
  • FRA16D
  • Fragile site FRA16D oxidoreductase
  • SDR41C1
  • short chain dehydrogenase/reductase family 41C, member 1
  • WOX1
  • WOX1PRO0128
  • WW domain containing oxidoreductase
  • WW domain-containing oxidoreductase
  • WW domain-containing protein WWOX
  • WWOX

Background

WWOX, also known as WW domain containing oxidoreductase, is a proapoptotic protein and a tumor suppressor protein. WWOX is found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This protein may function synergistically with TP53/p53 to control genotoxic stress-induced cell death. It also plays a role in tumor necrosis factor (TNF)-mediated cell death. Recombinant human WWOX protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

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Bioinformatics

Gene Symbol WWOX
Entrez