WNK1 Antibody [PerCP]

• Reactivity: Mu, Rt
• Applications: WB, Flow
• Clonality: Polyclonal
• Host: Goat
• Conjugate: PerCP

WNK1 Antibody [PerCP] Summary

• Immunogen: E. coli-derived recombinant rat WNK1
  Ser816-Ser1173
  Accession # Q9JIH7
• Specificity: Detects mouse and rat WNK1 in Western blots.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: WNK1
• Purity: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Flow Cytometry
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: PBS
• Preservative: 0.05% Sodium Azide
• Purity: Antigen Affinity-purified

Alternate Names for WNK1 Antibody [PerCP]

• EC 2.7.11
• EC 2.7.11.1
• Erythrocyte 65 kDa protein
• HSAN2hereditary sensory neuropathy, type II
• HSN2MGC163339
• hWNK1
• KDP
• KDPMGC163341
• KIAA0344
• Kinase deficient protein
• p65
• PHA2C
• PRKWNK1
• PRKWNK1PSK
• prostate-derived sterile 20-like kinase
• Protein kinase lysine-deficient 1
• Protein kinase with no lysine 1
• protein kinase, lysine deficient 1
• serine/threonine-protein kinase WNK1
• WNK lysine deficient protein kinase 1
• WNK1

Background

WNK lysine deficient protein kinase 1 (WNK1) is a cytoplasmic serine-threonine kinase expressed in the distal nephron which likely plays an important role in hypertension. WNK1 is responsible for controling Na+ and Cl- ion transport by inhibiting the activity of other related protein kinases, such as WNK4.

WNK1 mutations have been associated with Gordon hyperkalemia-hypertension syndrome (pseudohypoaldosteronism type II) and congenital sensory neuropathy.

WNK1 is also known as Human Accelerated Region 5, and is thought to have played a key role in differentiating humans from apes.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: WNK1