WNK1 Products

Description

WNK lysine deficient protein kinase 1 (WNK1) is a cytoplasmic serine-threonine kinase expressed in the distal nephron which likely plays an important role in hypertension. WNK1 is responsible for controling Na+ and Cl- ion transport by inhibiting the activity of other related protein kinases, such as WNK4.

WNK1 mutations have been associated with Gordon hyperkalemia-hypertension syndrome (pseudohypoaldosteronism type II) and congenital sensory neuropathy.

WNK1 is also known as Human Accelerated Region 5, and is thought to have played a key role in differentiating humans from apes.

Bioinformatics

Entrez	116477 Rat 232341 Mouse 378465 Human 65125 Human
Uniprot	NP_061852 Human Q6IFS5 Human Q9H4A3 Human
Product By Gene ID	65125
Alternate Names	EC 2.7.11 EC 2.7.11.1 Erythrocyte 65 kDa protein HSAN2hereditary sensory neuropathy, type II HSN2MGC163339 hWNK1 KDPMGC163341 KIAA0344 Kinase deficient protein p65 PHA2C PRKWNK1PSK prostate-derived sterile 20-like kinase Protein kinase lysine-deficient 1 Protein kinase with no lysine 1 protein kinase, lysine deficient 1 serine/threonine-protein kinase WNK1 WNK lysine deficient protein kinase 1

Research Areas for WNK1

Find related products by research area and learn more about each of the different research areas below.

Phospho-Specific
Protein Kinase
Signal Transduction
Transcription Factors and Regulators