VIAAT/SLC32A1/VGAT Antibody (731307) [Alexa Fluor® 647]

• Reactivity: Hu
• Applications: ICC/IF
• Clone: 731307
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 647

VIAAT/SLC32A1/VGAT Antibody (731307) [Alexa Fluor® 647] Summary

• Immunogen: E. coli-derived recombinant human VIAAT/SLC32A1
  Ala2-Phe133
  Accession # Q9H598
• Specificity: Detects human VIAAT/SLC32A1 in direct ELISAs.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for VIAAT/SLC32A1/VGAT Antibody (731307) [Alexa Fluor® 647]

• bA122O1.1
• hVIAAT
• SLC32A1
• solute carrier family 32 (GABA vesicular transporter), member 1
• Solute carrier family 32 member 1
• Vesicular GABA transporter
• vesicular inhibitory amino acid transporter
• VGAT
• VGATGABA and glycine transporter
• VIAAT

Background

VIAAT (Vesicular inhibitory amino acid transporter; also VGAT and SLC32A1) is a 56-58 kDa member of the amino acid/polyamine transporter 2 family of proteins. It is expressed in inhibitory neurons throughout the CNS, in both resting and activated lymphocytes, and in pancreatic alpha -cells (in rodent). VIAAT is believed to transport both GABA and glycine across synaptic vesicle membranes in an electrical and pH gradient-dependent manner. Once transported, these neurotransmitters are released at the presynaptic membrane, acting as inhibitory factors in the mature nervous system, and excitatory factors in the immature nervous system. Human VIAAT is a 525 amino acid (aa) 10-transmembrane nonglycosylated protein. The N-terminus (aa 1-133) and C-terminus (aa 511-525) are cytoplasmic. There is a 52 kDa short form that is not well characterized. Over aa 2-133, human VIAAT shares 95% aa identity with mouse VIAAT.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.