VAP-1/AOC3 Antibody (393106) [Alexa Fluor® 405]


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Product Details

Reactivity HuSpecies Glossary
Applications Flow
Alexa Fluor 405
Please see the vial label for concentration. If unlisted please contact technical services.

VAP-1/AOC3 Antibody (393106) [Alexa Fluor® 405] Summary

S. frugiperda insect ovarian cell line Sf 21-derived recombinant human VAP‑1/AOC3
Accession # Q16853
Detects human VAP‑1/AOC3 in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant mouse VAP‑1 is observed.
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  • Intracellular Staining by Flow Cytometry 0.25-1 ug/10^6 cells
Application Notes
Flow Cytometry: Please use 0.25-1 ug of conjugated antibody per 10e6 cells.

Packaging, Storage & Formulations

Store the unopened product at 2 - 8 °C. Do not use past expiration date.
Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.
0.09% Sodium Azide
Please see the vial label for concentration. If unlisted please contact technical services.


This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for VAP-1/AOC3 Antibody (393106) [Alexa Fluor® 405]

  • amine oxidase, copper containing 3 (vascular adhesion protein 1)
  • AOC3
  • Copper amine oxidase
  • EC 1.4.3
  • HPAO
  • Semicarbazide-sensitive amine oxidase
  • SSAO
  • VAP1
  • VAP-1
  • VAP1EC
  • VAP-1membrane primary amine oxidase
  • Vascular adhesion protein 1


Vascular adhesion protein-1 (VAP-1) is a copper amine oxidase with a topaquinone cofactor. VAP-1 is a Type II integral membrane protein, but a soluble form of the enzyme is present in human serum, and its level increases in diabetes and some inflammatory liver diseases (1, 2). VAP-1 catalyzes the oxidative deamination of small primary amines such as methylamine, benzylamine, and aminoacetone in a reaction that produces an aldehyde, ammonia, and H2O2 (3). The enzyme is sensitive to inhibition by semicarbazide. VAP-1 expression is highest in the endothelium of lung, heart, and intestine, but low in tissues such as brain, spleen, kidney, and liver (4). VAP-1 vascular expression is regulated at sites of inflammation through its release from intracellular granules in which the protein is stored (5). The adhesive function of VAP-1 has been demonstrated in studies showing that the protein is important for the adherence of certain lymphocyte subtypes to inflamed endothelial tissues (6). VAP-1 mediated adhesion is involved in the process of leukocyte extravasation, an important feature of inflammatory responses. The role of VAP-1 amine oxidase activity in this process is not fully defined, but it appears to be carbohydrate-dependent (7). VAP-1 is considered to be a therapeutic target for diabetes, oxidative stress, and inflammatory diseases (8).

  1. Kurkijärvi, R. et al. (1998) J. Immunol. 161:1549.
  2. Gearing, A.J.H. and W. Newman (1993) Immunol. Today 14:506.
  3. Lizcano, J.M. et al. (1998) Biochem. J. 331:69.
  4. Smith, D.J. et al. (1998) J. Exp. Med. 188:17.
  5. Jaakkala K. et al. (2000) Am. J. Pathol. 157:463.
  6. Salmi, M. and J. Jalkanen (2001) Trends Immunol. 22:211.
  7. Salmi, M. and J. Jalkanen (1996) J. Exp. Med. 183:569.
  8. Dunkel, P. et al. (2008) Curr. Med. Chem. 15:1827.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies


Isotype Controls

Other Available Formats

Alexa Fluor 350 IC39571U
Alexa Fluor 405 IC39571V
Alexa Fluor 488 IC39571G
Alexa Fluor 594 IC39571T
Alexa Fluor 647 IC39571R
Alexa Fluor 700 IC39571N
Alexa Fluor 750 IC39571S

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Gene Symbol AOC3