VAMP3/Cellubrevin Antibody

Western Blot: VAMP3/Cellubrevin Antibody [NBP2-24480] - analysis of VAMP-3 in human brain lysate in the 1) absence and 2) presence of immunizing peptide 3) mouse brain and 4) rat brain using this antibody. 0 ug/ml.

Product Discontinued

VAMP3/Cellubrevin Antibody Summary

• Immunogen: A portion of amino acids 1-50 of human VAMP-3 was used as the immunogen.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: VAMP3
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Western Blot 0.5-2.0 ug/ml

Reactivity Notes

Predicted to cross react with New World monkey

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: 0.2 ml PBS and 0.05% BSA
• Preservative: 0.05% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for VAMP3/Cellubrevin Antibody

• CEBCellubrevin
• cellubrevin
• SYB3
• Synaptobrevin-3
• VAMP-3
• vesicle-associated membrane protein 3 (cellubrevin)
• vesicle-associated membrane protein 3

Background

A novel member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family, VAMP-3 is a v-SNARE protein that resides in recycling endosomes and endosome-derived transport vesicles. It colocalizes with endocytosed transferrin receptors and the glucose transporter GLUT4 in adipocytes, and is also present in alpha-granules in platelets. The protein has been implicated in recycling of transferrin receptors to the plasma membrane, secretion of alpha-granules in platelets, recycling of T-cell receptors to the immunological synapses, and membrane trafficking during cell migration. It is a homologue of VAMP-2 and has a broad tissue distribution in humans. Like VAMP-2, it can be cleaved by tetanus toxin, a metallo-endoprotease which blocks synaptic exocytosis. In humans, the VAMP-3 gene is mapped to chromosome 1p36.23.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: VAMP3
• Uniprot:
  • Q15836(Human)