VAChT/SLC18A3 Antibody Blocking Peptide

• Reactivity: Hu
• Applications: AC
• Concentration: LYOPH

VAChT/SLC18A3 Antibody Blocking Peptide Summary

• Description: A VAChT/SLC18A3 antibody blocking peptide.
• Protein/Peptide Type: Antibody Blocking Peptide
• Gene: SLC18A3

Applications/Dilutions

• Dilutions:
  • Antibody Competition
• Application Notes: This peptide is useful as a blocking peptide for NB100-91348. For further blocking peptide related protocol, click here.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Concentration: LYOPH
• Reconstitution Instructions: Reconstitute to desired concentration using sterile water. Centrifuge to remove any insoluble material. Glycerol may be added (1:1) for additional stability.

Notes

Maintain refrigerated at 2-8 degrees C for up to 12 months. After reconstitution keep at -20 degrees C. Avoid freeze and thaw cycles. This peptide is soluble in PBS and water.

Alternate Names for VAChT/SLC18A3 Antibody Blocking Peptide

• MGC12716
• SLC18A3
• solute carrier family 18 (vesicular acetylcholine), member 3
• Solute carrier family 18 member 3
• solute carrier family 18, member 3
• VAChT
• VACHTvesicular acetylcholine transporter

Background

Vesicular Acetylcholine Transporter (VAChT), (approx. 70kD protein), belongs to the family of vesicular monoamine transporters(VMATs), which include VMAT1 and VMAT2 and the C.elegans putative ACh transporter unc-17. Members of this family function to concentrate neurotransmitters into synaptic vesicles through exchange of protons for neurotransmitters. VAChT is a functional transporter for the neurotransmitter acetylcholine(ACh). ACh is synthesized in the cytoplasm by choline acetyl transferase (ChAT) and transported by VAChT into synaptic vesicles where it is stored until released. After release from presynaptic nerve terminals ACh is hydrolyzed by extracellular ACh-esterases(AChE) to choline and acetate. VAChT mRNA is expressed in all known major cholinergic neurons in the central and peripheral nervous system. VAChT is abundantly expressed in the CNS and is mainly localized in small synaptic vesicles in cholinergic nerve terminals. VAChT provides a specific marker for cholinergic neurons for the study of cholinergic transmission in experimental models, in Alzheimer's disease and other nervous system disorders.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

Bioinformatics

• Gene Symbol: SLC18A3