uPAR Antibody (VIM-5)

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow, IHC, IHC-Fr, IP
Clone
VIM-5
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated

Order Details

uPAR Antibody (VIM-5) Summary

Immunogen
THP-1 cells (Human acute monocytic leukaemia cells).
Isotype
IgG
Clonality
Monoclonal
Host
Mouse
Gene
PLAUR
Purity
Protein G purified
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Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Flow Cytometry 1:50 - 1:200
  • Immunohistochemistry
  • Immunohistochemistry-Frozen 1:100
  • Immunoprecipitation
Application Notes
For Flow cytometry: Use 10 uL of the suggested working dilution to label 1x10^6 cells in 100 uL.

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.09% Sodium Azide
Purity
Protein G purified

Alternate Names for uPAR Antibody (VIM-5)

  • CD87 antigen
  • CD87
  • Monocyte activation antigen Mo3
  • plasminogen activator, urokinase receptor
  • PLAUR
  • uPAR
  • U-PAR
  • UPARurokinase plasminogen activator surface receptor
  • u-plasminogen activator receptor form 2
  • URKRMO3

Background

The urokinase-type plasminogen activator (uPA) is one of two activators that converts the extracellular zymogen plasminogen to plasmin, a serine protease that is involved in a variety of normal and pathological processes that require cell migration and/or tissue destruction. uPA is synthesized and released from cells as a single-chain (sc) pro-enzyme with limited enzymatic activity and is converted to an active two-chain (tc) disulfide-linked active enzyme by plasmin and other specific proteinases. Both the scuPA and tcuPA bind with high-affinity to the cell surface via the glycosyl phosphatidylinositol-linked receptor uPAR which serves to localize the uPA proteolytic activity. The enzymatic activity of scuPA has also been shown to be enhanced by binding to uPAR. Independent of their proteolytic activity, the uPA/uPAR interaction also initiates signal transduction responses resulting in activation of protein tyrosine kinases, gene expression, cell adhesion, and chemotaxis. uPAR can interact with integrins to suppress normal integrin adhesive function and promote adhesion to vitronectin through a high affinity vitronectin binding site on uPAR.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

Isotype Controls

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Calculators

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Bioinformatics

Gene Symbol PLAUR