Recombinant Human ULBP-2 His Protein

SDS-Page: Recombinant Human ULBP-2 Protein [NBP2-59528] - 15% SDS-PAGE (3ug)

• Reactivity: Hu
• Applications: PAGE
• Concentration: 0.5 mg/ml

Recombinant Human ULBP-2 His Protein Summary

• Description: A recombinant protein with a C-Terminal His-tag and corresponding to the amino acids 26-216 of Human ULBP-2
  
  

  Source:Baculovirus

  Amino Acid Sequence: ADPGRADPHS LCYDITVIPK FRPGPRWCAV QGQVDEKTFL HYDCGNKTVT PVSPLGKKLN VTTAWKAQNP VLREVVDILT EQLRDIQLEN YTPKEPLTLQ ARMSCEQKAE GHSSGSWQFS FDGQIFLLFD SEKRMWTTVH PGARKMKEKW ENDKVVAMSF HYFSMGDCIG WLEDFLMGMD STLEPSAGAP LAMSHHHHHH

• Source: Baculovirus
• Protein/Peptide Type: Recombinant Protein
• Gene: ULBP2
• Purity: >90%, by SDS-PAGE
• Endotoxin Note: < 1.0 EU per 1 microgram of protein (determined by LAL method)

Applications/Dilutions

• Dilutions:
  • SDS-Page
• Theoretical MW: 22.7 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.4), 10% glycerol
• Preservative: No Preservative
• Concentration: 0.5 mg/ml
• Purity: >90%, by SDS-PAGE

Alternate Names for Recombinant Human ULBP-2 His Protein

• ALCAN-alpha
• N2DL2
• N2DL-2
• NKG2D ligand 2
• NKG2DL2
• RAET1H
• RAET1HNKG2DL2
• retinoic acid early transcript 1 H
• Retinoic acid early transcript 1H
• UL16 binding protein 2
• UL16-binding protein 2
• ULBP2
• ULBP-2

Background

Ligand for the NKG2D receptor, together with at least ULBP1 and ULBP3. ULBPs activate multiple signalingpathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands toNKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transductionpathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked theinteraction with the NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system.UL16 also causes ULBP2 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

Bioinformatics

• Gene Symbol: ULBP2