ULBP-2 Products

Description

Ligand for the NKG2D receptor, together with at least ULBP1 and ULBP3. ULBPs activate multiple signalingpathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands toNKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transductionpathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked theinteraction with the NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system.UL16 also causes ULBP2 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface

Bioinformatics

Entrez	80328 Human
Uniprot	NM_025217 Human Q9BZM5 Human AAH34689 Human
Product By Gene ID	80328
Alternate Names	retinoic acid early transcript 1 H N2DL-2 NKG2D ligand 2 ALCAN-alpha UL16-binding protein 2 Retinoic acid early transcript 1H RAET1HNKG2DL2 N2DL2 UL16 binding protein 2

Diseases related to ULBP-2

Discover more about diseases related to ULBP-2.

Neoplasms
Malignant Neoplasms
Carcinoma
Leukemia
Cytomegalovirus Infections
Malignant Paraganglionic Neoplasm
Melanoma
Tumor Escape
Neoplasm Metastasis
Myeloid Leukemia
Ovarian Neoplasm
Leukemia, Myelocytic, Acute
Infective Disorder
Lymphoma
Lung Neoplasms
Hiv Infections
Immunologic Deficiency Syndromes
Liver Carcinoma
Liver Diseases

Pathways for ULBP-2

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Immune Response
Cytolysis
Cell Activation
Cell Recognition
Secretion
Cell Proliferation
Transport
Cell Cycle
Innate Immune Response
Exocytosis
Cell Killing
Senescence
Methylation
Cell Death
Cell Growth
Rna Interference
Lymphocyte Activation
Cell Adhesion
Gene Silencing
Chemokine Production

PTMs for ULBP-2

Learn more about PTMs related to ULBP-2.

Cleavage
Phosphorylation
Methylation
Demethylation
Glycosylation
Gpi Anchoring

Bioinformatics Tool for ULBP-2

Discover related pathways, diseases and genes to ULBP-2. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.