Species: Hu
Applications: B/N
Host: Mouse Monoclonal
Species: Hu
Applications: WB, ELISA, Flow, ICC/IF
Host: Mouse Polyclonal
Species: Hu
Applications: WB
Species: Hu
Applications: Binding Activity
Species: Hu
Applications: PAGE
Description
Ligand for the NKG2D receptor, together with at least ULBP1 and ULBP3. ULBPs activate multiple signalingpathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands toNKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transductionpathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked theinteraction with the NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system.UL16 also causes ULBP2 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface
Bioinformatics
| Entrez |
Human
|
| Uniprot |
Human
Human
Human
|
| Product By Gene ID |
80328 |
| Alternate Names |
- retinoic acid early transcript 1 H
- N2DL-2
- NKG2D ligand 2
- ALCAN-alpha
- UL16-binding protein 2
- Retinoic acid early transcript 1H
- RAET1HNKG2DL2
- N2DL2
- UL16 binding protein 2
|
Bioinformatics Tool for ULBP-2
Discover related pathways, diseases and genes to ULBP-2. Need help? Read the
Bioinformatics Tool Guide for instructions on using this tool.
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