UFD1L Antibody

Western Blot: UFD1L Antibody [NBP1-03339] - Detection of Human UFD1 on HeLa whole cell lysate using NBP1-03339. UFD1 was also immunoprecipitated by rabbit anti-UFD1 antibody NBP1-03338.

• Reactivity: Hu, Mu
• Applications: WB, IP
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Concentration: 0.2 mg/ml

UFD1L Antibody Summary

• Immunogen: The immunogen recognized by this antibody maps to a region between residue 257 and 307 of human ubiquitin fusion degradation 1 using the numbering given in entry NP_005650.2 (GeneID 7353).
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: UFD1
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunoprecipitation 1:10-1:500
  • Western Blot 1:2000-1:10000
• Control:

  UFD1L Overexpression Lysate

Reactivity Notes

Mouse reactivity reported in scientific literature (PMID: 27913212).

Packaging, Storage & Formulations

• Storage: Store at 4C. Do not freeze.
• Buffer: TBS and 0.1% BSA
• Preservative: 0.09% Sodium Azide
• Concentration: 0.2 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for UFD1L Antibody

• ATP1C
• ATP1G1ATPase, Na+/K+ transporting, gamma 1 polypeptide
• FXYD domain containing ion transport regulator 2
• FXYD domain-containing ion transport regulator 2
• HOMG2
• hypomagnesemia 2, renal
• MGC12372
• Na(+)/K(+) ATPase subunit gamma
• Sodium pump gamma chain
• sodium/potassium-transporting ATPase subunit gamma
• Sodium-potassium-ATPase, gamma polypeptide

Background

The protein encoded by the UFD1L gene forms a complex with two other proteins, nuclear protein localization-4 and valosin-containing protein, and this complex is necessary for the degradation of ubiquitinated proteins. In addition, this complex controls the disassembly of the mitotic spindle and the formation of a closed nuclear envelope after mitosis. Mutations in this gene have been associated with Catch 22 syndrome as well as cardiac and craniofacial defects. Alternative splicing results in multiple transcript variants encoding different isoforms. A related pseudogene has been identified on chromosome 18. (provided by RefSeq)

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for UFD1L Antibody (NBP1-03339)(1)

Publication using NBP1-03339

• Guo X, Qi X. VCP cooperates with UBXD1 to degrade mitochondrial outer membrane protein MCL1 in model of Huntington's disease. Biochim. Biophys. Acta. 2016-11-29 [PMID: 27913212] (WB, Mouse)

Bioinformatics

• Gene Symbol: UFD1
• Entrez:
  • 7353(Human)
• Uniprot:
  • NP_005650.2(Human)