Ubiquilin 2 Antibody (6H9) [DyLight 755]

• Reactivity: Hu, Mu, Rt
• Applications: WB, ICC/IF, IHC, IP, KD, KO
• Clone: 6H9
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: DyLight 755

Ubiquilin 2 Antibody (6H9) [DyLight 755] Summary

• Immunogen: Human Ubiquilin 2 expressed in and purified from E. coli [UniProt# Q9UHD9]
• Localization: Cytoplasm. Nucleus.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: UBQLN2
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Frozen
  • Immunoprecipitation
  • Knockdown Validated
  • Knockout Validated
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein G purified

Notes

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for Ubiquilin 2 Antibody (6H9) [DyLight 755]

• Chap1
• CHAP1/DSK2
• DSK2 homolog
• DSK2
• FLJ10167
• FLJ56541
• hPLIC-2
• N4BP4LIC-2
• Nedd4 binding protein 4
• PLIC-2
• PLIC2Dsk2
• Protein linking IAP with cytoskeleton 2
• RIHFB2157
• ubiquilin 2
• ubiquilin-2
• Ubiquitin-like product Chap1/Dsk2

Background

Ubiquilin 2 encodes an ubiquitin-like protein (ubiquilin) that shares high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain a N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases, and thus thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to bind the ATPase domain of the Hsp70-like Stch protein.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: UBQLN2