TSPAN7/TM4SF2 Antibody (482618) [Alexa Fluor™ Plus 594]

• Reactivity: Hu
• Clone: 482618
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor Plus 594

TSPAN7/TM4SF2 Antibody (482618) [Alexa Fluor™ Plus 594] Summary

• Specificity: Stains human TSPAN7 transfectants but not irrelevant transfectants in flow cytometry.
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for TSPAN7/TM4SF2 Antibody (482618) [Alexa Fluor™ Plus 594]

• A15
• A15CCG-B7
• CCG-B7
• CD231 antigen
• CD231
• Cell surface glycoprotein A15
• DXS1692E
• Membrane component chromosome X surface marker 1
• mental retardation, X-linked 58
• MRX58
• MXS1
• MXS1T-cell acute lymphoblastic leukemia associated antigen 1
• TALLA-1
• T-cell acute lymphoblastic leukemia-associated antigen 1
• tetraspanin 7
• tetraspanin-7
• TM4SF2
• TM4SF2b
• TM4SF2tetraspanin protein
• transmembrane 4 superfamily 2b
• Transmembrane 4 superfamily member 2X chromosome, surface marker 1
• transmembrane protein A15
• TSPAN7
• tspan-7

Background

Tetraspanin-7 (aka TSPAN7,  TALLA-1, TM4SF2 and CD231) is a 249 aminoacids (aa) multi-pass membrane protein.  Tetraspanin proteins regulate morphology, signaling and trafficking processes by interaction and association with proteins in tetraspanin enriched microdomains (TEMs). It has been proposed that tetraspanins interact with integrins to affect cell migration, probably by modulation or compartmentalization of integrin signaling. TSPAN7 has been found to be upregulated in myeloma development and described as a prognostic marker of renal cell carcinoma. Mutations in TSPAN7 are also implicated in some forms of X-linked intellectual disability.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.