TSG Antibody - BSA Free

Immunocytochemistry/Immunofluorescence: TSG Antibody [NBP1-80660] - Immunofluorescent staining of human cell line U-251 MG shows localization to cytosol & centrosome.

Immunohistochemistry-Paraffin: TSG Antibody [NBP1-80660] - Staining of human stomach shows strong cytoplasmic positivity in glandular cells.

• Reactivity: Hu, Mu, Rt
• Applications: ICC/IF, IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free

TSG Antibody - BSA Free Summary

• Immunogen: This antibody was developed against Recombinant Protein corresponding to amino acids: DECCDCVGMCNPRNYSDTPPTSKSTVEELHEPIPSLFRALTEGDTQLNWNIVSFPVAEELSHHENLVSFLETVNQPHHQNVSVPSNNVHAPYSSDKEHMCTVVYFDDCMSIHQCKISCESMGASKYRWFHNACCECIGPECIDYGSKTVK
• Predicted Species: Mouse (97%), Rat (97%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: TWSG1
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence 0.25-2 ug/ml
  • Immunohistochemistry 1:50 - 1:200
  • Immunohistochemistry-Paraffin 1:50 - 1:200
• Application Notes: For IHC-Paraffin, HIER pH 6 retrieval is recommended. Immunocytochemistry/Immunofluorescence Fixation Permeabilization: Use PFA/Triton X-100.
• Control Peptide:

  TSG Protein (NBP1-80660PEP)

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.2) and 40% Glycerol
• Preservative: 0.02% Sodium Azide
• Purity: Immunogen affinity purified

Alternate Names for TSG Antibody - BSA Free

• TSG
• TSGtwisted gastrulation protein homolog 1
• twisted gastrulation homolog 1 (Drosophila)
• TWSG1

Background

Twisted Gastrulation Protein 1(TWSG1) is a secreted BMP binding protein structurally related to the BMP antagonists Chordin and Noggin. TSG can inhibit BMP activity by binding directly to BMP proteins thereby preventing BMPs from binding to their receptors. It can act either as a BMP4 agonist or antagonist (depending on the specific biochemical environment) by binding to the BMP4/Chordin complex.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for TSG Antibody (NBP1-80660)(3)

Publications using NBP1-80660

• Shankar S, Hsu ZT, Ezquerra A et al. Α gamma -tubulin complex-dependent pathway suppresses ciliogenesis by promoting cilia disassembly Cell reports 2022-11-15 [PMID: 36384111] (WB, Human)
• Burton AR, Guillaume SM, Foster WS et al. The memory B cell response to influenza vaccination is impaired in older persons Cell reports 2022-11-08 [PMID: 36351385] (Human)
• Larman BW, Karolak MJ, Adams DC et al. Chordin-like 1 and twisted gastrulation 1 regulate BMP signaling following kidney injury. J Am Soc Nephrol 2009-05-01 [PMID: 19357253]

Bioinformatics

• Gene Symbol: TWSG1
• Entrez:
  • 57045(Human)