TRPA1 Antibody

Images

 
Immunohistochemistry-Paraffin: TRPA1 Antibody [NB110-55520] - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
Immunohistochemistry-Paraffin: TRPA1 Antibody [NB110-55520] - Analysis of anti-TRPA1 antibody with human spinal cord, dorsal root ganglion at concentration 20 ug/ml.

Product Details

Summary
Reactivity Hu, Mk, PmSpecies Glossary
Applications IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1.0 mg/ml

Order Details

TRPA1 Antibody Summary

Immunogen
Synthetic 18 amino acid peptide from internal region of human TRPA1.
Epitope
internal domain of human
Localization
Cell Membrane
Specificity
Human TRPA1. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Predicted Species
Primate (94%), Monkey (100%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
TRPA1
Purity
Immunogen affinity purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Immunohistochemistry-Paraffin 10-20 ug/ml

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Gibbon (100%), Marmoset (94%), Canine (89%), Bovine (89%), Elephant (89%), Rat (83%), Bat (83%), Panda (83%), Equine (83%), Rabbit (83%).

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.1% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for TRPA1 Antibody

  • ANKTM1ankyrin-like with transmembrane domains 1
  • Ankyrin-like with transmembrane domains protein 1
  • Transformation-sensitive protein p120
  • transient receptor potential cation channel subfamily A member 1
  • transient receptor potential cation channel, subfamily A, member 1

Background

TRPA1 is a TRP-related channel that responds to cold temperatures and pungent compounds that include the cold-mimetic icilin and cannabinoids. TRPA1 is a transformation-associated gene product in lung epithelia, whereas its protein distribution is primarily restricted to sensory neurons. It is now known that TRPA1 protein is also widely expressed outside the CNS and is indeed dys-regulated during oncogenic transformation; TRPA1 associates with the tumor-suppressor protein CYLD.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

Isotype Controls

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Blogs on TRPA1.

Winter is coming, and TRPM8 welcomes the cold!
TRPM8, or transient receptor potential melastatin 8, is a nonselective cation channel that is activated by cold environments and menthol-like cooling compounds.  While TRPM8 is best known for its location in peripheral nerve endings, it has functio...  Read full blog post.

TRPA1: A contributor to itching and inflammation? Scratch that!
Transient receptor potential A1 (TRPA1) is an ion channel found on the plasma membrane of many cell types that functions in diverse sensory processes such as pain and temperature. The TRPA1 ion channel is specifically expressed in nociceptive neurons,...  Read full blog post.

Touch Infographic: From Touch Receptors to the Brain
The body contains thousands of receptors and nerves which allow us to experience the sense of touch, also referred to as tactile perception. The somatosensory system allows organisms to perceive and decode a wide range of tactile stimuli to allow for...  Read full blog post.

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Bioinformatics

Gene Symbol TRPA1
Entrez