TREML1/TLT-1 Antibody (268420) [Alexa Fluor® 647]

Human peripheral blood platelets were stained with (A) Rat Anti-Human TREML1/TLT-1 Alexa Fluor® 647-conjugated Monoclonal Antibody (Catalog # FAB2394R) or (B) Rat IgG2B Isotype Control (Catalog # IC013R) and Mouse Anti-Human Integrin alpha 2b/CD41 PE-conjugated Monoclonal Antibody (Catalog # FAB7616P). View our protocol for Staining Membrane-associated Proteins.

• Reactivity: Hu
• Applications: Flow
• Clone: 268420
• Clonality: Monoclonal
• Host: Rat
• Conjugate: Alexa Fluor 647
• Concentration: Please see the vial label for concentration. If unlisted please contact technical services.

TREML1/TLT-1 Antibody (268420) [Alexa Fluor® 647] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant human TREML1/TLT‑1
  Gln16-Ser160
  Accession # Q86YW5
• Specificity: Detects human TREML1/TLT‑1 in direct ELISAs and Western blots. In direct ELISAs, no cross‑reactivity with recombinant mouse TREML1 or recombinant human TREML2 is observed.
• Source: N/A
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Rat
• Gene: TREML1
• Purity Statement: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Flow Cytometry 0.25-1 ug/10^6 cells
• Application Notes: Flow Cytometry: Please use 0.25-1 ug of conjugated antibody per 10e6 cells.

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.
• Buffer: Supplied in a saline solution containing BSA and Sodium Azide.
• Preservative: 0.09% Sodium Azide
• Concentration: Please see the vial label for concentration. If unlisted please contact technical services.
• Reconstitution Instructions: Reconstitution default not known

Notes

This product is provided under an agreement between Life Technologies Corporation and R&D Systems, Inc, and the manufacture, use, sale or import of this product is subject to one or more US patents and corresponding non-US equivalents, owned by Life Technologies Corporation and its affiliates. The purchase of this product conveys to the buyer the non-transferable right to use the purchased amount of the product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components (1) in manufacturing; (2) to provide a service, information, or data to an unaffiliated third party for payment; (3) for therapeutic, diagnostic or prophylactic purposes; (4) to resell, sell, or otherwise transfer this product or its components to any third party, or for any other commercial purpose. Life Technologies Corporation will not assert a claim against the buyer of the infringement of the above patents based on the manufacture, use or sale of a commercial product developed in research by the buyer in which this product or its components was employed, provided that neither this product nor any of its components was used in the manufacture of such product. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, Cell Analysis Business Unit, Business Development, 29851 Willow Creek Road, Eugene, OR 97402, Tel: (541) 465-8300. Fax: (541) 335-0354.

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for TREML1/TLT-1 Antibody (268420) [Alexa Fluor® 647]

• dJ238O23.3
• GLTL1825
• PRO3438
• TLT1
• TLT-1
• TLT1MGC119173
• TREML1
• trem-like transcript 1 protein
• triggering receptor expressed on myeloid cells-like 1
• Triggering receptor expressed on myeloid cells-like protein 1

Background

TREML1 is an inhibitory type I transmembrane protein that has two cytoplasmic ITIMs (Immunoreceptor Tyrosine-based Inhibition Motif). A splice variant lacking ITIMs in its cytoplasmic domain also exists. TREML1 is found only in platelets and megakaryocytes.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for TREML1/TLT-1 Antibody (FAB2394R)(1)

Publication using FAB2394R

• T Vögtle, S Sharma, J Mori, Z Nagy, D Semeniak, C Scandola, MJ Geer, CW Smith, J Lane, S Pollack, R Lassila, A Jouppila, AJ Barr, DJ Ogg, TD Howard, HJ McMiken, J Warwicker, C Geh, R Rowlinson, WM Abbott, A Eckly, H Schulze, GJ Wright, A Mazharian, K Fütterer, S Rajesh, MR Douglas, YA Senis Heparan sulfates are critical regulators of the inhibitory megakaryocyte-platelet receptor G6b-B Elife, 2019-08-22;8(0):. 2019-08-22 [PMID: 31436532] (Flow Cytometry, Mouse)

Bioinformatics

• Gene Symbol: TREML1
• Uniprot:
  • Q86YW5()