TORC3/CRTC3 Antibody (643729) [Alexa Fluor® 350]

• Reactivity: Mu
• Applications: WB
• Clone: 643729
• Clonality: Monoclonal
• Host: Rat
• Conjugate: Alexa Fluor 350

TORC3/CRTC3 Antibody (643729) [Alexa Fluor® 350] Summary

• Immunogen: E. coli-derived recombinant mouse TORC3
  Leu153-Pro275
  Accession # Q91X84
• Specificity: Detects mouse TORC3 in direct ELISAs and Western blots. In direct ELISAs, less than 15% cross-reactivity with recombinant human TORC3 and no cross-reactivity with recombinant mouse (rm) TORC1 or rmTORC2 is observed.
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Rat
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for TORC3/CRTC3 Antibody (643729) [Alexa Fluor® 350]

• CREB regulated transcription coactivator 3
• CRTC3
• FLJ21868
• TORC3
• TORC-3
• TORC3CREB-regulated transcription coactivator 3
• Transducer of CREB protein 3
• transducer of regulated cAMP response element-binding protein (CREB) 3
• Transducer of regulated cAMP response element-binding protein 3
• transducer of regulated CREB protein 3

Background

TORC3, also known as CREB-regulated transcription coactivator 1 (crtc3), is an approximately 80 kDa protein that functions as a coactivator for CREB1 in promoting transcription through both consensus and variant cAMP response element (CRE) sites. TORC3 activity is important in regulating the expression of genes involved in cellular energy metabolism. Its binding to the HTLV-1 protein Tax enhances HTLV-1 transcription, whereas its binding to cellular Bcl3 inhibits HTLV-1 transcription. Alternate splicing of mouse TORC3 generates isoforms that lack the N-terminal 299 amino acids (aa). Within aa 153-275, mouse TORC3 shares 99% and 98% aa sequence identity with human and rat TORC3, respectively.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.