TORC2 Antibody (628430) [Alexa Fluor® 750]

• Reactivity: Hu, Mu
• Applications: WB
• Clone: 628430
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 750

TORC2 Antibody (628430) [Alexa Fluor® 750] Summary

• Immunogen: E. coli-derived recombinant human TORC2
  Lys453-Ser613
  Accession # Q53ET0
• Specificity: Detects human and mouse TORC2 in Western blots.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for TORC2 Antibody (628430) [Alexa Fluor® 750]

• CREB regulated transcription coactivator 2
• CREB-regulated transcription coactivator 2
• CRTC2
• TORC2
• TORC-2
• TORC2transducer of regulated cAMP response element-binding protein (CREB) 2
• Transducer of CREB protein 2
• Transducer of regulated cAMP response element-binding protein 2

Background

TORC2, also known as CREB-regulated transcription co-activator 1 (crtc2), is an approximately 75 kDa protein that functions as a co‑activator for CREB1 in promoting transcription through both consensus and variant cAMP response element (CRE) sites. TORC2 activity is important in regulating the expression of genes involved in cellular energy metabolism. Its O-glycosylation triggers TORC2-dependent induction of hepatic gluconeogenic enzymes. It mediates hypothalamic glucose sensing and also the sensing of endoplasmic reticulum stress. In addition, TORC2 contributes to the transcription of HTLV-1 genes and the activation of latent EBV infections. Within aa 453‑613, human TORC2 shares 84% aa sequence identity with mouse TORC2.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.