LASS2 Antibody (1A6)

Images

 
Western Blot: LASS2 Antibody (1A6) [H00029956-M01A] - Human neuroblastoma cells untreated or treated with various drugs. Image from verified customer review.
Western Blot: LASS2 Antibody (1A6) [H00029956-M01A] - S2 monoclonal antibody (M01), clone 1A6 Western Blot analysis of LASS2 expression in HepG2.
Western Blot: LASS2 Antibody (1A6) [H00029956-M01A] - S2 monoclonal antibody (M01), clone 1A6. Western Blot analysis of LASS2 expression in NIH/3T3.

Product Details

Summary
Reactivity Hu, MuSpecies Glossary
Applications WB, ELISA, IHC-P
Clone
1A6
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated

Order Details

LASS2 Antibody (1A6) Summary

Immunogen
LASS2 (AAH01357, 1 a.a. ~ 380 a.a) full-length recombinant protein with GST tag.MLQTLYDYFWWERLWLPVNLTWADLEDRDGRVYAKASDLYITLPLALLFLIVRYFFELYVATPLAALLNIKEKTRLRAPPNATLEHFYLTSGKQPKQVEVELLSRQSGLSGRQVERWFRRRRNQDRPSLLKKFREASWRFTFYLIAFIAGMAVIVDKPWFYDMKKVWEGYPIQSTIPSQYWYYMIELSFYWSLLFSIASDVKRKDFKEQIIHHVATIILISFSWFANYIRAGTLIMALHDSSDYLLESAKMFNYAGWKNTCNNIFIVFAIVFIITRLVILPFWILHCTLVYPLELYPAFFGYYFFNSMMGVLQLLHIFWAYLILRMAHKFITGKLVEDERSDREETESSEGEEAAAGGGAKSRPLANGHPILNNNHRKND
Specificity
LASS2 - LAG1 longevity assurance homolog 2 (S. cerevisiae) (1A6)
Isotype
IgM Kappa
Clonality
Monoclonal
Host
Mouse
Gene
CERS2
Purity
Unpurified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:500
  • ELISA 1:100-1:2000
  • Immunohistochemistry-Paraffin
Application Notes
Antibody reactive against cell lysate and recombinant protein for western blot. It has also been used for ELISA. Use in Immunohistochemistry-Paraffin reported in scientific literature (PMID 27255818).
Positive Control
Kidney Lysate (NB820-59661)
Publications
Read Publications using
H00029956-M01A in the following applications:

  • WB
    2 publications

Packaging, Storage & Formulations

Storage
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer
Ascites
Preservative
No Preservative
Purity
Unpurified

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for LASS2 Antibody (1A6)

  • ceramide synthase 2
  • CerS2
  • LAG1 homolog, ceramide synthase 2
  • LAG1 longevity assurance 2
  • LAG1 longevity assurance homolog 2 (S. cerevisiae)
  • LAG1 longevity assurance homolog 2
  • S. cerevisiae) homolog 2
  • SP260MGC987
  • TMSG1
  • Tumor metastasis-suppressor gene 1 protein

Background

This gene encodes a protein that has sequence similarity to yeast longevity assurance gene 1. Mutation or overexpression of the related gene in yeast has been shown to alter yeast lifespan. The human protein may play a role in the regulation of cell growth. Alternatively spliced transcript variants encoding the same protein have been described.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for LASS2 Antibody (H00029956-M01A)(7)

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 1 application: WB.


Filter By Application
WB
(2)
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Human
(1)
Mouse
(1)
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Showing Publications 1 - 7 of 7.
Publications using H00029956-M01A Applications Species
Couttas TA, Kain N, Suchowerska AK et al. Loss of ceramide synthase 2 activity, necessary for myelin biosynthesis, precedes tau pathology in the cortical pathogenesis of Alzheimer's Disease. Neurobiol Aging. 2016 Apr 4 [PMID: 27255818]
Couttas TA, Kain N, Suchowerska AK et al. Loss of ceramide synthase 2 activity, necessary for myelin biosynthesis, precedes tau pathology in the cortical pathogenesis of Alzheimer's Disease. Neurobiol Aging. 2016 Apr 4 [PMID: 27255818]
Novgorodov SA, Riley CL, Keffler JA et al. SIRT3 Deacetylates Ceramide Synthases: Implications for Mitochondrial Dysfunction and Brain Injury. J. Biol. Chem. 2015 Nov 30 [PMID: 26620563] (WB, Mouse) WB Mouse
Separovic D, Breen P, Joseph N et al. siRNA-Mediated Down-regulation of Ceramide Synthase 1 Leads to Apoptotic Resistance in Human Head and Neck Squamous Carcinoma Cells after Photodynamic Therapy Anticancer Res 2012 Jul [PMID: 22753704]
Separovic D, Breen P, Joseph N et al. Ceramide synthase 6 knockdown suppresses apoptosis after photodynamic therapy in human head and neck squamous carcinoma cells. Anticancer Res. 2012 Mar 01 [PMID: 22399588]
Mullen TD, Spassieva S, Jenkins RW et al. Selective knockdown of ceramide synthases reveals complex interregulation of sphingolipid metabolism. J Lipid Res. Jan. 2011 [PMID: 20940143] (WB, Human) WB Human
Siskind LJ, Mullen TD, Romero Rosales K et al. The BCL-2 protein BAK is required for long-chain ceramide generation during apoptosis. J Biol Chem 285(16):11818-26. 2010 Apr 16. [PMID: 20172858]

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Product General Protocols

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Positive Control Lysate(s)

Secondary Antibodies

 

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Bioinformatics

Gene Symbol CERS2
Entrez
Uniprot