TIMP-2 Antibody (F27 P3 A4)

Images

 
Immunocytochemistry/ Immunofluorescence: TIMP-2 Antibody (F27 P3 A4) [NB100-74552] - Cells were grown on chamber slides and fixed with formaldehyde prior to staining. Cells were probed without (control) or with a TIMP2 ...read more
Immunohistochemistry-Paraffin: TIMP-2 Antibody (F27 P3 A4) [NB100-74552] - Normal biopsies of deparaffinized Mouse pancreas tissue at a dilution of 1:100.
Immunocytochemistry/ Immunofluorescence: TIMP-2 Antibody (F27 P3 A4) [NB100-74552] - Cells were grown on chamber slides and fixed with formaldehyde prior to staining. Cells were probed without (control) or with a TIMP2 ...read more
Immunocytochemistry/ Immunofluorescence: TIMP-2 Antibody (F27 P3 A4) [NB100-74552] - Cells were grown on chamber slides and fixed with formaldehyde prior to staining. Cells were probed without (control) or with a TIMP2 ...read more
Immunohistochemistry-Paraffin: TIMP-2 Antibody (F27 P3 A4) [NB100-74552] - Normal biopsies of deparaffinized Human pancreas tissue at a dilution of 1:500.

Product Details

Summary
Reactivity Hu, Mu, Rt, Bv, Ch, RbSpecies Glossary
Applications WB, ICC/IF, IHC, IHC-P
Clone
F27 P3 A4
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
1 mg/ml

Order Details

TIMP-2 Antibody (F27 P3 A4) Summary

Immunogen
Synthetic peptide corresponding to residues D(56) S G N D I Y G N P I(66) of mouse TIMP-2.
Localization
Secreted
Predicted Species
Rat (100%), Chicken (100%), Bovine (100%), Rabbit (100%). Backed by our 100% Guarantee.
Isotype
IgG2a Kappa
Clonality
Monoclonal
Host
Mouse
Gene
TIMP2
Purity
Protein A purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:500
  • Immunocytochemistry/Immunofluorescence 1 - 2 ug/ml
  • Immunohistochemistry 1:100 - 1:500
  • Immunohistochemistry-Paraffin 1:50 - 1:500
Application Notes
WB: Detects an approx. 18-24 kDa protein representing TIMP-2 from mouse platelets. It is recommended to block with 3% BSA.

Reactivity Notes

Please note that this antibody is reactive to Mouse and derived from the same host, Mouse. Additional Mouse on Mouse blocking steps may be required for IHC and ICC experiments. Please contact Technical Support for more information.

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
PBS with 1 mg/ml BSA
Preservative
0.05% Sodium Azide
Concentration
1 mg/ml
Purity
Protein A purified

Alternate Names for TIMP-2 Antibody (F27 P3 A4)

  • CSC-21Ktissue inhibitor of metalloproteinase 2
  • metalloproteinase inhibitor 2
  • TIMP metallopeptidase inhibitor 2
  • TIMP2
  • TIMP-2
  • Tissue inhibitor of metalloproteinases 2

Background

Tissue inhibitor of metalloproteinases-1 (TIMP-1) and Tissue inhibitor of metalloproteinases-2 (TIMP-2) are inhibitory enzymes of matrix metalloproteinase family. TIMP-1 forms a complex of 1:1 stoichiometry with activated interstitial collagenase, activated stromelysin, active form of 72 kD Type IV collagenase (MMP-2) and latent and active forms 92 kD Type IV collagenase (MMP-9). TIMPs inhibit the proteolytic invasiveness of tumor cells and normal placental trophoblast cells.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol
ICC/IF Video Protocol

FAQs for TIMP-2 Antibody (NB100-74552) (0)

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

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Bioinformatics Tool for TIMP-2 Antibody (NB100-74552)

Discover related pathways, diseases and genes to TIMP-2 Antibody (NB100-74552). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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Research Areas for TIMP-2 Antibody (NB100-74552)

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Blogs on TIMP-2.

Suppressing breast cancer metastasis: The role of hypoxia-induced RhoB expression and activation
By Jamshed Arslan, Pharm. D., PhD. The Ras homologous (Rho) GTPase family of signaling molecules has over 20 members, which typically cycle between active (GTP-bound) and inactive (GDP-bound) states. These small GTPa...  Read full blog post.

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Bioinformatics

Gene Symbol TIMP2
Entrez
Uniprot