TIMP-1 Antibody (MM0034-4A16) Summary
This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse immunized with purified recombinant human tissue inhibitor of metalloproteinases-1 (TIMP-1).
Protein G purified
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- Western Blot 1:100-1:1000
- Immunohistochemistry 1:10-1:500
- Immunohistochemistry-Paraffin 1:25-1:50
Packaging, Storage & Formulations
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
A 0.2 um filtered solution in PBS
Protein G purified
Reconstitute with 0.5 ml sterilized PBS to a final concentration of 0.2 mg/ml.
Alternate Names for TIMP-1 Antibody (MM0034-4A16)
- Collagenase inhibitor
- collagenase inhibitor)
- erythroid potentiating activity
- Erythroid-potentiating activity
- Fibroblast collagenase inhibitor
- metalloproteinase inhibitor 1
- TIMP metallopeptidase inhibitor 1
- TIMPtissue inhibitor of metalloproteinase 1 (erythroid potentiating activity
- Tissue inhibitor of metalloproteinases 1
Tissue inhibitor of metalloproteinases 1 (TIMP1) and Tissue inhibitor of metalloproteinases 2 (TIMP 2) have similar properties, specifically in inhibiting enzymes of matrix metalloproteinase family, and are thought to be of great importance in the maintenance of connective tissue integrity. TIMP1 forms a complex of 1:1 stoichiometry with activated interstitial collagenases, activated stromelysin, active form of 72kDa Type IV collagenase (also known as MMP2 or gelatinase A), and latent and active forms 92kDa Type IV collagenase (also known as MMP0 or gelatinase B). TIMPs inhibit the proteolytic invasiveness of tumour cells and normal placental trophoblast cells. TIMP1 is produced in low (pg/ml) levels by most cell types. Treatment of cells with the phorbol ester TPA stimulates production of TIMP1 in some cell types, but the low protein levels produced often require concentration of cell culture media to visualize the bands by Western Blotting.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed
for 1 year from date of receipt.
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