TIMP-1 Products

Description

Tissue inhibitor of metalloproteinases 1 (TIMP1) and Tissue inhibitor of metalloproteinases 2 (TIMP 2) have similar properties, specifically in inhibiting enzymes of matrix metalloproteinase family, and are thought to be of great importance in the maintenance of connective tissue integrity. TIMP1 forms a complex of 1:1 stoichiometry with activated interstitial collagenases, activated stromelysin, active form of 72kDa Type IV collagenase (also known as MMP2 or gelatinase A), and latent and active forms 92kDa Type IV collagenase (also known as MMP0 or gelatinase B). TIMPs inhibit the proteolytic invasiveness of tumour cells and normal placental trophoblast cells. TIMP1 is produced in low (pg/ml) levels by most cell types. Treatment of cells with the phorbol ester TPA stimulates production of TIMP1 in some cell types, but the low protein levels produced often require concentration of cell culture media to visualize the bands by Western Blotting.

Bioinformatics

Entrez	116510 Rat 21857 Mouse 7076 Human
Uniprot	AAH00866.1 Human NM_003254 Human NM_003254.2 Human NP_003245.1 Human P01033 Human P01033 Human P12032 Mouse
Product By Gene ID	7076
Alternate Names	CLGI Collagenase inhibitor collagenase inhibitor) EPATIMP-1 EPO erythroid potentiating activity Erythroid-potentiating activity Fibroblast collagenase inhibitor FLJ90373 HCI metalloproteinase inhibitor 1 TIMP metallopeptidase inhibitor 1 TIMPtissue inhibitor of metalloproteinase 1 (erythroid potentiating activity Tissue inhibitor of metalloproteinases 1

Research Areas for TIMP-1

Find related products by research area and learn more about each of the different research areas below.

Angiogenesis
Cancer
Cell Biology
Cell Cycle and Replication
Cellular Markers
Cytoskeleton Markers
Extracellular Matrix