Thyroid Peroxidase Antibody (MoAb47)

Product Discontinued

Thyroid Peroxidase Antibody (MoAb47) Summary

• Immunogen: Human Thyroid Peroxidase (hTPO) purified from thyroid microsomes by immunoaffinity chromatography.
• Localization: Cytoplasmic
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: TPO
• Purity: Tissue culture supernatant

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 1:10-1:25

Reactivity Notes

Human

Packaging, Storage & Formulations

• Storage: Store at 4C. Do not freeze.
• Buffer: Tissue culture supernatant
• Preservative: 0.09% Sodium Azide
• Purity: Tissue culture supernatant

Alternate Names for Thyroid Peroxidase Antibody (MoAb47)

• EC 1.11.1
• MSA
• TDH2A
• thyroid microsomal antigen
• thyroid peroxidase
• thyroperoxidase
• TPXEC 1.11.1.8

Background

Principal Names: Thyroid peroxidase Official Gene Symbol: TPO Gene ID: 7173 (Human) Gene Map Locus: 2p25 (Human). Thyroid peroxidase is a key enzyme in thyroid hormone biosynthesis and one of the major antigen in thyroid autoimmune disease. It is a type I glycosylated transmembrane protein localized to the apical part of thyroid follicular cells. It catalyzes iodide oxidation, iodination of tyrosine residues and coupling of iodotyrosines to generate the iodothyronines T4 and T3. The enzymatic reactions of TPO require the presence of iodide, H2O2 and thyroglobulin. The single-copy human gene, located on the short arm of chromosome 2p25 is comprised of 17 exons and 16 introns spanning about 150 kb. Its expression is under the control of thyroid-specific transcription factors such as TTF-1, TTF-2 and PAX. Multiple transcript variants encoding distinct isoforms have been identified for the protein.The pathological role of the protein has been identified in Grave's disease and total iodide organification defect (TIOD).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: TPO