TGF-beta RIII Antibody

Product Discontinued

TGF-beta RIII Antibody Summary

• Immunogen: Peptide with sequence C-TKSIRDDIPSTQGN corresponding to internal region according to NP_003234.2.
• Epitope: C terminus
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: TGFBR3
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Peptide ELISA Detection limit 1:32000
• Application Notes: WB: Preliminary experiments gave an approx. 38 kDa band in human placenta, lymph node, and tonsil lysates and in lysates of Daudi, Jurkat and MOLT4 after 0.5 ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 93.5 kDa band according to NP_003234.2. The 38 kDa band was successfully blocked by incubation with the immunizing peptide.

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: Tris (pH 7.3), 0.5% BSA
• Preservative: 0.02% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Immunogen affinity purified

Notes

Please note, this antibody is considered Innovators Grade. Innovators Grade antibodies are generally unvalidated and require additional characterization for most new species/applications. Novus has made these antibodies available through our Innovators Reward program. Complete an online review with image, detailing your positive or negative results. In return, you receive a discount voucher for 100% of the purchase price of the reviewed product. Please contact us at innovators@novusbio.com for more details.

Alternate Names for TGF-beta RIII Antibody

• betaglycan proteoglycan
• Betaglycan
• BGCAN
• TBRIII
• TGF-beta receptor type 3
• TGF-beta receptor type III
• TGF-beta RIII
• TGFbetaRIII
• TGFBR3
• TGF-bRIII
• TGFR-3
• Transforming growth factor beta receptor III
• transforming growth factor beta receptor type 3
• transforming growth factor, beta receptor III (betaglycan, 300kDa)
• transforming growth factor, beta receptor III

Background

Transforming growth factor (TGF)-beta is a multifunctional cytokine that modulates several tissue development and repair processes, including cell differentiation, cell cycle progression, cellular migration, adhesion, and extracellular matrix production. Three TGF-beta forms are encoded by separate genes: TGFB1 (MIM 190180), TGFB2 (MIM 190220), and TGFB3 (MIM 190230). The diverse effects of TGF-beta are mediated by the TGF-beta receptors and cell surface-binding proteins. Three TGF-beta receptors exist: type I (TGFBR1; MIM 190181), type II (TFGBR2; MIM 190182), and type III (TGFBR3). TGFBR3 is a glycoprotein that binds TGFB and exists in both a membrane-bound and a soluble form (Johnson et al., 1995 [PubMed 8530052]).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for TGF-beta RIII Antibody (NBP1-20983)(1)

Publication using NBP1-20983

• Woszczyk D, Gola J, Jurzak M et al. Expression of TGF beta1 genes and their receptor types I, II, and III in low- and high-grade malignancy non-Hodgkin's lymphomas. Med Sci Monit 2004-01-01 [PMID: 14704634]

Bioinformatics

• Gene Symbol: TGFBR3
• Entrez:
  • 7049(Human)
• Uniprot:
  • NP_003234.2(Human)