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TGF-beta RIII Antibody (Jack-1)

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Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP1-97647
    • Availability
      Product Discontinued

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TGF-beta RIII Antibody (Jack-1) Summary

Immunogen
Recombinant human TGF-betaRIII cytoplasmic domain (aa 809-850).
Isotype
IgG2b
Clonality
Monoclonal
Host
Mouse
Gene
TGFBR3
Purity
Protein G purified
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Applications/Dilutions

Dilutions
  • Immunoprecipitation 1:200
  • Western Blot 1:1000
Application Notes
NBP1-97647 is >95% pure by SDS-PAGE.

Reactivity Notes

Human

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.02% Sodium Azide
Concentration
1.0 mg/ml
Purity
Protein G purified

Alternate Names for TGF-beta RIII Antibody (Jack-1)

  • betaglycan proteoglycan
  • Betaglycan
  • BGCAN
  • TBRIII
  • TGF-beta receptor type 3
  • TGF-beta receptor type III
  • TGF-beta RIII
  • TGFbetaRIII
  • TGFBR3
  • TGF-bRIII
  • TGFR-3
  • Transforming growth factor beta receptor III
  • transforming growth factor beta receptor type 3
  • transforming growth factor, beta receptor III (betaglycan, 300kDa)
  • transforming growth factor, beta receptor III

Background

TGF-B receptor III (TGF-BRIII; betaglycan) is an ubiquitously expressed transmembrane proteoglycan TGF-B co-receptor that regulates TGF-B signalling by increasing the binding of TGF-B to the subunit II or TGF-B receptor. (Note: The TGF-B receptor III is a co-receptor of TGF-B receptor, composed of subunit I and II; TGF-B receptor III increases the binding of TGF-B to the subunit II. In this way it can regulate the signaling.) TGF-B receptor III expression is lost in many human breast and prostate cancers and correlates with the resistance to the tumor suppressor effects of TGF-B . The overexpression of TGF-B receptor III in breast cancer cells suppresses their tumorigenicity in an animal model.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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TGF-beta RIII
Antibody (Jack-1)
NBP1-97647
TGF-beta RIII Antibody (Jack-1)
Species: Hu
Applications: WB, IP

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Transforming growth factor-beta receptor III (TGF-beta RIII) is one of three receptors for the secreted growth factor TGF-beta. Unlike type I and type II TGF-beta receptors, TGF-beta RIII does not participate directly in the propagation of intracel...  Read full blog post.

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Bioinformatics

Gene Symbol TGFBR3