TGF-beta RII Antibody (DMC467) - Chimeric

• Reactivity: Hu
• Applications: Flow
• Clone: DMC467
• Clonality: Monoclonal
• Host: Human
• Conjugate: Unconjugated
• Concentration: LYOPH

TGF-beta RII Antibody (DMC467) - Chimeric Summary

• Description: This product is shipped at ambient temperature. Store at -20C to -80C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80C (Avoid repeated freezing and thawing).
• Additional Information: Recombinant Monoclonal Antibody
• Immunogen: TGF-beta RII recombinant protein expressed in mammalian cells (Accession# P37173). The exact amino acid sequence is proprietary.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Human
• Gene: TGFBR2
• Purity: Antigen Affinity-purified from cell culture supernatant

Applications/Dilutions

• Dilutions:
  • Flow Cytometry 1:100

Packaging, Storage & Formulations

• Storage: Store at -20C in powder form. Store at -80C once reconstituted.
• Buffer: PBS, pH 7.4, 5-8% Trehalose
• Preservative: Trehalose
• Concentration: LYOPH
• Purity: Antigen Affinity-purified from cell culture supernatant
• Reconstitution Instructions: Dissolve the lyophilized antibody in sterile and low endotoxin water. The recommend volume of water is lot specific. Please refer to the instructions printed on the product vial or contact technical support.

Alternate Names for TGF-beta RII Antibody (DMC467) - Chimeric

• AAT3
• EC 2.7.11
• EC 2.7.11.30
• FAA3
• HNPCC6
• LDS1B
• LDS2B
• MFS2
• RIIC
• TAAD2
• tbetaR-II
• TGF-beta receptor type II
• TGF-beta receptor type IIB
• TGF-beta receptor type-2
• TGF-beta RII
• TGF-beta type II receptor
• TGFbetaRII
• TGFbeta-RII
• TGFBR2
• TGF-bRII
• TGFR-2
• transforming growth factor beta receptor type IIC
• transforming growth factor, beta receptor II (70/80kDa) isoform 1
• transforming growth factor, beta receptor II (70/80kDa) isoform 2
• transforming growth factor, beta receptor II (70/80kDa)
• transforming growth factor, beta receptor II (70-80kD)
• Transforming growth factor-beta receptor type II

Background

TGF beta Receptor II is a total of three members of the TGFbeta family, TGFbeta1, TGFbeta2 and TGFbeta3, have been identified in mammals. Each is synthesized as a latent precursor that is subsequently cleaved forming the 112 amino acid growth factor which becomes active upon dimerization. TGFbetas mediate their activity by high affinity binding to the type II receptor (TGFbeta RII) transmembrane protein with a cytoplasmic serine-threonine kinase domain. For signaling growth inhibition and early gene responses the type II receptor requires both its kinase activity and association with a TGFbeta-binding protein, designated the type I receptor. Two independent groups have recently described the cloning and sequence analysis of genes encoding TGFbeta type I receptor proteins designated ALK-5 (TbetaR-1) and TSR-1, respectively.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: TGFBR2