TGF-beta Antibody (1D11.16.8) [DyLight 755]

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Product Details

Summary
Reactivity Hu, Mu, Rt, Bv, Ca, Ha, MkSpecies Glossary
Applications IHC-P
Clone
1D11.16.8
Clonality
Monoclonal
Host
Mouse
Conjugate
DyLight 755

TGF-beta Antibody (1D11.16.8) [DyLight 755] Summary

Immunogen
Bovine TGF-beta2 protein
Localization
Cytoplasm and extracellular (secreted)
Specificity
This MAb recognizes TGF beta 1, 2 and 3. Three TGF betas have been identified in mammals. TGFbeta1, TGFbeta2 and TGFbeta3 are each synthesized as precursor proteins that are very similar in that each is cleaved to yield a 112 amino acid polypeptide that remains associated with the latent portion of the molecules. Biologically active TGFbeta requires dimerization of the monomers (usually homodimers) and release of the latent peptide portion. Overall, the mature region of the TGFbeta3 protein has approximately 80% identity to the mature region of both TGFbeta1 and TGFbeta2. However, the NH2 terminals or precursor regions of their molecules share only 27% sequence identity. TGFbeta's inhibit the growth of epithelial cells and stimulate the growth of mesenchymal cells.
Isotype
IgG1 Kappa
Clonality
Monoclonal
Host
Mouse
Gene
TGFB1
Purity
Protein A or G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry-Paraffin
Application Notes
Optimal dilution of this antibody shomld be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified

Notes

Dylight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for TGF-beta Antibody (1D11.16.8) [DyLight 755]

  • CED
  • DPD1
  • LAP
  • TGFB
  • TGFB1
  • TGFbeta
  • TGF-beta
  • transforming growth factor beta 1

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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Array NBP2-47736IR

Bioinformatics Tool for TGF-beta Antibody (NBP2-47736IR)

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Diseases for TGF-beta Antibody (NBP2-47736IR)

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PTMs for TGF-beta Antibody (NBP2-47736IR)

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Blogs on TGF-beta.

TGF-beta for treating degenerative intervertebral disc disease
By Jamshed Arslan Pharm.D. Our upright posture and balance depend on a jelly-like material, called nucleus pulposus (NP), in the middle of intervertebral discs. NP cells protect us from disc degeneration by maintain...  Read full blog post.

Stemness for Surviving Hypoxia: TGF-beta/Smad Signaling in Multiple Myeloma
By Jamshed Arslan Pharm.D. Multiple myeloma (MM) is a cancer of antibody-producing plasma cells. The bone marrow (BM) of MM patients is hypoxic, and MM cells overexpress many cancerous genes that are regulated by hy...  Read full blog post.

TGF-beta RIII - A multi-functional regulator of the TGF-beta signaling pathway
Transforming growth factor-beta receptor III (TGF-beta RIII) is one of three receptors for the secreted growth factor TGF-beta. Unlike type I and type II TGF-beta receptors, TGF-beta RIII does not participate directly in the propagation of intracel...  Read full blog post.

CCR2 or CD192
CCR2 is a receptor for several monocyte chemoattractant proteins (MCP1, MCP3, MCP4) that specifically govern monocyte chemotaxis. CCR2 transduces its downstream signals through increasing intracellular calcium ion levels. For example, MCP1 regulate...  Read full blog post.

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Bioinformatics

Gene Symbol TGFB1