TFF1/pS2 Antibody Blocking Peptide

Product Discontinued

TFF1/pS2 Antibody Blocking Peptide Summary

• Description: A TFF1/pS2 antibody blocking peptide.
• Immunogen: Synthetic peptide corresponding to 15aa of mouse TFF1 (Accession #Q08423), C-terminal
• Protein/Peptide Type: Antibody Blocking Peptide
• Gene: TFF1

Applications/Dilutions

• Dilutions:
  • Antibody Competition
• Application Notes: This peptide is useful as a blocking peptide for NBP2-13163. Suitable for use in ELISA and Antibody Blocking. Not suitable for Western Blot.
  
  For further blocking peptide related protocol, click here.
• Theoretical MW: 3 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: lyophilized powder from PBS
• Preservative: 0.05% Sodium Azide
• Reconstitution Instructions: Please contact technical services for info.

Alternate Names for TFF1/pS2 Antibody Blocking Peptide

• BCEI
• BCEIbreast cancer, estrogen-inducible sequence expressed in
• Breast cancer estrogen-inducible protein
• breast cancer estrogen-inducible sequence
• D21S21
• gastrointestinal trefoil protein pS2
• hP1.A
• HPS2
• PNR-2
• Polypeptide P1.A
• Protein pS2
• PS2
• TFF1
• trefoil factor 1
• trefoil factor, BCE1, human pS2 induced by estrogen from human breast cancercell line M10HP1.A

Background

Minor disruption of the GI surface layer of the cells occurs frequently, such that maintaining epithelial integrity is of crucial importance. Normal epithelial repair requires restitution and regeneration. During restitution, within minutes after injury, epithelial cells spread and migrate across the basement membrane to re-establish surface cell continuity. Trefoil factor family (TFF) proteins play an important role in restitution by influencing the migration of cells without promotion of proliferation or tumorigenesis. Regeneration occurs later on and involves proliferation and differentiation of epithelial cells and restoration of specialized elements. Three mouse TFFs have been identified to date TFF1 (formerly pS2) and TFF3 (formerly hITF), with one trefoil domain each, and TFF2 (formerly hSP), with two trefoil domains. TFF1 rat: 81aa; human: 84aa; mouse: 87aa - 9.67kD; Mouse chromosome: 17A3.3 . Expressed in a number of carcinomas including breast (50%), pancreas (70-75%), stomach (50-55%), and large bowel (58%).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: TFF1