TET1 Antibody [FITC]

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Product Details

Summary
Reactivity MuSpecies Glossary
Applications IHC, IHC-P, ICC/IF (-), WB (-)
Clonality
Polyclonal
Host
Rabbit

TET1 Antibody [FITC] Summary

Immunogen
A synthetic peptide made to an internal portion of the human TET1 protein (between residues 1700 to 1800) [UniProt Q8NFU7]
Localization
Nucleus and cytoplasm.
Clonality
Polyclonal
Host
Rabbit
Gene
TET1
Purity
Immunogen affinity purified
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Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Conjugate
FITC
Format
FITC (A=495, E=519)
Buffer
PBS
Preservative
0.05% Sodium Azide
Purity
Immunogen affinity purified

Applications/Dilutions

Dilutions
  • Immunohistochemistry 1:400
  • Immunohistochemistry-Paraffin 1:400
Application Notes
This TET1 antibody is useful for and Immunohistochemistry on paraffin embedded sections. In IHC-P, staining was observed in the nucleus and cytoplasm of mouse spleen tissue. Prior to immunostaining paraffin tissues, antigen retrieval with sodium citrate buffer (pH 6.0) is recommended. This antibody is not recommended for Western Blot or Immunocytochemistry/Immunofluorescence.

Reactivity Notes

Mouse

Alternate Names for TET1 Antibody [FITC]

  • bA119F7.1
  • CXXC finger 6
  • CXXC6
  • CXXC6FLJ10839
  • FLJ41442
  • KIAA1676CXXC-type zinc finger protein 6
  • LCX
  • LCXEC 1.14.11.n2
  • Leukemia-associated protein with a CXXC domain
  • methylcytosine dioxygenase TET1
  • Ten-eleven translocation 1 gene protein
  • ten-eleven translocation-1
  • tet oncogene 1

Background

TET1 (Tet methylcytosine dioxygenase 1, LCX, CXXC6) is a member of a novel protein family. This family of proteins may play a role in epigenetic regulation via modification of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (hmC). TET1 is a fusion partner of the MLL gene in acute myeloid leukemia (PMID: 19372391). It has been shown that TET1 supports DNA demethylation in mammalian cells via the base excision repair pathway where TET1 converts 5mC to hmC. Additionally, TET1 is integral to neuronal activity-induced, region specific, active DNA demethylation and subsequent gene expression in the dentate gyrus of the adult mouse brain in vivo. This suggests that the mechanism for active DNA demethylation in mammals is through TET1-induced oxidation-deamination (PMID: 21496894).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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Contact Information

Product PDFs

Bioinformatics

Gene Symbol TET1

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