Tensin 1 Antibody [DyLight 350]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, ICC/IF, IHC, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
DyLight 350

Tensin 1 Antibody [DyLight 350] Summary

Immunogen
Tensin 1 antibody made to partial recombinant protein made to the N-terminal portion of human Tensin 1 (amino acids 1-385) [UniProt Q9HBL0].
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
TNS1
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot
  • Immunocytochemistry/Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Immunogen affinity purified

Notes



DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for Tensin 1 Antibody [DyLight 350]

  • DKFZp586K0617
  • matrix-remodelling associated 6
  • Matrix-remodelling-associated protein 6
  • MGC88584
  • MST091
  • MST122
  • MST127
  • MSTP127
  • MXRA6
  • tensin 1
  • tensin
  • tensin-1
  • TNSMSTP122

Background

Tensin 1 (TNS1, human Tensin 1 theoretical molecular weight 186kDa) belongs to a family of focal adhesion proteins which in mammals includes three other members: Tensin 2, Tensin 3, and C-terminal tensin-like (Cten or Tensin 4) (1, 2). Tensins localize to focal adhesion sites, which are functional domains of the cellular membrane that mediate interactions between the actin cytoskeleton and the extracellular matrix (1). Transmembrane integrin receptors (alpha-beta heterodimer) predominate within focal adhesions and serve to bridge the interactions between extracellular components and the cytoskeleton (3). Tensin 1 interacts with both actin filaments and beta-integrin receptors within focal adhesion sites to mediate cellular responses to extracellular signals (1, 4). Several common functional domains are shared between some tensin family members including: 1) amino terminal PTEN-related tyrosine phosphatase (PTP) domain, 2) amino terminal actin-binding (ABD-1) domain, 3) amino terminal focal adhesion binding (FAB-N) domain, 4) carboxy terminal Src homology 2 (SH2) domain, 5) carboxy terminal phosphotyrosine binding (PTB) domain, and 6) carboxy terminal focal adhesion binding (FAB-C) domain (4). The PTB domain allows tensins to interact with beta-integrin cytoplasmic tails, while their SH2 domain supports interaction with tyrosine-phosphorylated signaling proteins (1). The interactions of tensins with focal adhesion kinases and phosphatases support diverse cellular processes such as attachment, migration, and polarization. Loss of function studies have revealed that tensin 1 plays a critical role for normal kidney function, skeletal muscle regeneration and angiogenesis (1).

References

1. Lo, S. H. (2017). Tensins. Current Biology. https://doi.org/10.1016/j.cub.2017.02.041

2. Lo, S. H. (2014). C-terminal tensin-like (CTEN): A promising biomarker and target for cancer. International Journal of Biochemistry and Cell Biology. https://doi.org/10.1016/j.biocel.2014.04.003

3. Armitage, S. K., & Plotnikov, S. V. (2016). Bridging the gap: A new study reveals that a protein called talin forms a vital link between microtubules and focal adhesions at the surface of cells. ELife. https://doi.org/10.7554/eLife.19733

4. Lo, S. H. (2006). Focal adhesions: What's new inside. Developmental Biology. https://doi.org/10.1016/j.ydbio.2006.03.029

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Alexa Fluor 350 NBP2-78783AF350
Alexa Fluor 405 NBP2-78783AF405
Alexa Fluor 488 NBP2-78783AF488
Alexa Fluor 532 NBP2-78783AF532
Alexa Fluor 594 NBP2-78783AF594
Alexa Fluor 647 NBP2-78783AF647
Alexa Fluor 700 NBP2-78783AF700
Alexa Fluor 750 NBP2-78783AF750
Biotin NBP2-78783B
DyLight 350 NBP2-78783UV
DyLight 405 NBP2-78783V
DyLight 488 NBP2-78783G
DyLight 550 NBP2-78783R
DyLight 594 NBP2-78783DL594
DyLight 650 NBP2-78783C
DyLight 680 NBP2-78783FR
DyLight 755 NBP2-78783IR
FITC NBP2-78783F
HRP NBP2-78783H
Janelia Fluor 549 NBP2-78783JF549
Janelia Fluor 646 NBP2-78783JF646

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Bioinformatics

Gene Symbol TNS1