Tensin 1 Products

Antibodies
Lysates
Tensin 1 293T Cell Transient ...
Tensin 1 293T Cell Transient Overe...
H00007145-T01
Species: Hu
Applications: WB
Proteins
Recombinant Human Tensin 1 GS ...
Recombinant Human Tensin 1 GST (N-...
H00007145-P01
Species: Hu
Applications: WB, ELISA, PA, PAGE, AP
Tensin 1 Recombinant Protein ...
Tensin 1 Recombinant Protein Antigen
NBP1-84130PEP
Species: Hu
Applications: AC
Tensin 1 Recombinant Protein ...
Tensin 1 Recombinant Protein Antigen
NBP1-84129PEP
Species: Hu
Applications: AC

Description

Tensin 1 (TNS1, human Tensin 1 theoretical molecular weight 186kDa) belongs to a family of focal adhesion proteins which in mammals includes three other members: Tensin 2, Tensin 3, and C-terminal tensin-like (Cten or Tensin 4) (1, 2). Tensins localize to focal adhesion sites, which are functional domains of the cellular membrane that mediate interactions between the actin cytoskeleton and the extracellular matrix (1). Transmembrane integrin receptors (alpha-beta heterodimer) predominate within focal adhesions and serve to bridge the interactions between extracellular components and the cytoskeleton (3). Tensin 1 interacts with both actin filaments and beta-integrin receptors within focal adhesion sites to mediate cellular responses to extracellular signals (1, 4). Several common functional domains are shared between some tensin family members including: 1) amino terminal PTEN-related tyrosine phosphatase (PTP) domain, 2) amino terminal actin-binding (ABD-1) domain, 3) amino terminal focal adhesion binding (FAB-N) domain, 4) carboxy terminal Src homology 2 (SH2) domain, 5) carboxy terminal phosphotyrosine binding (PTB) domain, and 6) carboxy terminal focal adhesion binding (FAB-C) domain (4). The PTB domain allows tensins to interact with beta-integrin cytoplasmic tails, while their SH2 domain supports interaction with tyrosine-phosphorylated signaling proteins (1). The interactions of tensins with focal adhesion kinases and phosphatases support diverse cellular processes such as attachment, migration, and polarization. Loss of function studies have revealed that tensin 1 plays a critical role for normal kidney function, skeletal muscle regeneration and angiogenesis (1).

References

1. Lo, S. H. (2017). Tensins. Current Biology. https://doi.org/10.1016/j.cub.2017.02.041

2. Lo, S. H. (2014). C-terminal tensin-like (CTEN): A promising biomarker and target for cancer. International Journal of Biochemistry and Cell Biology. https://doi.org/10.1016/j.biocel.2014.04.003

3. Armitage, S. K., & Plotnikov, S. V. (2016). Bridging the gap: A new study reveals that a protein called talin forms a vital link between microtubules and focal adhesions at the surface of cells. ELife. https://doi.org/10.7554/eLife.19733

4. Lo, S. H. (2006). Focal adhesions: What's new inside. Developmental Biology. https://doi.org/10.1016/j.ydbio.2006.03.029

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Product By Gene ID 7145
Alternate Names
  • tensin-1
  • MST122
  • Matrix-remodelling-associated protein 6
  • MST091
  • MGC88584
  • tensin
  • MXRA6
  • matrix-remodelling associated 6
  • MSTP127
  • DKFZp586K0617
  • TNSMSTP122
  • MST127
  • tensin 1

Pathways for Tensin 1

View related products by pathway and learn more about each of the pathways below.

Transport
Cell Migration
Protein Catabolic Process
Protein Transport
Catabolic Process
Localization

Research Areas for Tensin 1

Find related products by research area and learn more about each of the different research areas below.

Cell Cycle and Replication
Signal Transduction

Bioinformatics Tool for Tensin 1

Discover related pathways, diseases and genes to Tensin 1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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