Recombinant Human TC-PTP/PTPN2 Protein

Product Discontinued

Recombinant Human TC-PTP/PTPN2 Protein Summary

• Description: A recombinant protein with GST tag at N-terminal corresponding to the amino acids 1-387 of Human PTPN2 full-length ORF
  
  

  Source: Wheat Germ (in vitro)

  Amino Acid Sequence:MPTTIEREFEELDTQRRWQPLYLEIRNESHDYPHRVAKFPENRNRNRYRDVSPYDHSRVKLQNAENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESVKCAQYWPTDDQEMLFKETGFSVKLLSEDVKSYYTVHLLQLENINSGETRTISHFHYTTWPDFGVPESPASFLNFLFKVRESGSLNPDHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIEGAKCIKGDSSIQKRWKELSKEDLSPAFDHSPNKIMTEKYNGNRIGLEEEKLTGDRCTGLSSKMQDTMEENSESALRKRIREDRKATTAQKVQQMKQRLNENERKRKRPRLTDT

• Details of Functionality: This protein was produced in an in vitro wheat germ expression system that should preserve correct conformational folding that is necessary for biological function. While it is possible that this protein could display some level of activity, the functionality of this protein has not been explicitly measured or validated.
• Source: Wheat germ
• Protein/Peptide Type: Recombinant Protein
• Gene: PTPN2
• Purity: >80% by SDS-PAGE and Coomassie blue staining

Applications/Dilutions

• Dilutions:
  • ELISA
  • Immunoaffinity Purification
  • Protein Array
  • Western Blot
• Theoretical MW: 71.6 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Store at -80C. Avoid freeze-thaw cycles.
• Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH 8.0.
• Purity: >80% by SDS-PAGE and Coomassie blue staining

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for Recombinant Human TC-PTP/PTPN2 Protein

• protein tyrosine phosphatase, non-receptor type 2
• PTP2
• PTPN2
• PTPTPTN2
• T-cell protein tyrosine phosphatase
• T-cell protein-tyrosine phosphatase
• TCELLPTP
• TCPTP
• TC-PTP
• TCPTPEC 3.1.3.48
• tyrosine-protein phosphatase non-receptor type 2

Background

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. Three alternatively spliced variants of this gene, which encode isoforms differing at their extreme C-termini, have been described. The different C-termini are thought to determine the substrate specificity, as well as the cellular localization of the isoforms. Two highly related but distinctly processed pseudogenes that localize to distinct chromosomes have been reported. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 1 year from date of receipt.

FAQs for TC-PTP/PTPN2 Recombinant Protein (H00005771-P01). (Showing 1 - 1 of 1 FAQ).

1. What does it mean by TC-PTP/PTPN2? Does PTPN2 come with attached proteins?
   • TC-PTP and PTPN2 are indicating the same gene and its product. According to Unipro, the PTPN2 gene's product (protein) is Tyrosine-protein phosphatase non-receptor type 2. And its alternative name is "T-cell protein-tyrosine phosphatase" --> Short name: "TCPTP". In summary they are the same thing (probably along the history of discovery and characterization of the protein, many different names were used by the different labs; and then they unified to a common name)

Bioinformatics

• Gene Symbol: PTPN2