TC-PTP/PTPN2 Products

Description

PTPN2 is encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. Three alternatively spliced variants of this gene, which encode isoforms differing at their extreme C-termini, have been described. The different C-termini are thought to determine the substrate specificity, as well as the cellular localization of the isoforms. Two highly related but distinctly processed pseudogenes that localize to distinct chromosomes have been reported. [provided by RefSeq]

Bioinformatics

Entrez	5771 Human
Uniprot	NM_080423 Human NP_002819 Human NP_536347.1 Human P17706 Human Q96AU5 Human
Product By Gene ID	5771
Alternate Names	protein tyrosine phosphatase, non-receptor type 2 PTPTPTN2 T-cell protein tyrosine phosphatase T-cell protein-tyrosine phosphatase TCELLPTP TC-PTP TCPTPEC 3.1.3.48 tyrosine-protein phosphatase non-receptor type 2