Western Blot: Tau [p Thr231] Antibody [NB100-82249] - Western blot analysis of extract from mouse brain tissue using Tau (Ab-231) Antibody ( Lane 1 and 2) and Tau (phospho-Thr231) antibody ( Lane 3 and 4)
Immunohistochemistry: Tau [p Thr231] Antibody [NB100-82249] - Immunohistochemical analysis of paraffin-embedded rat hippocampal region tissue from a model with Alzheimer's Disease using Tau (phospho-Thr231) antibody.
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, and 50% glycerol.
0.02% Sodium Azide
Immunogen affinity purified
Alternate Names for Tau [p Thr231] Antibody
G protein beta1/gamma2 subunit-interacting factor 1
microtubule-associated protein tau
MTBT1Neurofibrillary tangle protein
Neurofibrillary tangle protein
TAUPaired helical filament-tau
Tau is a neuronal microtubule associated protein found predominantly on axons. The function of Tau is to promote tubulin polymerisation and stabilise microtubules, but it also serves to link certain signalling pathways to the cytoskeleton. Tau, in its hyperphosphorylated form, is the major component of paired helical filaments (PHF) and neurofibrillary lesions in Alzheimer's disease (AD) brain. Hyperphosphorylation impairs the microtubule binding function of Tau, resulting in the destabilisation of microtubules in AD brains, ultimately leading to the degeneration of the affected neurons. Hyperphosphorylated tau is also found in a range of other central nervous system disorders. Numerous serine/threonine kinases, including GSK3 beta, PKA, Cdk5, and casein kinase II can phosphorylate Tau.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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