Tankyrase 1 Antibody

Images

 
Western Blot: Tankyrase 1 Antibody [NBP1-36994] - HEK293 overexpressing TANK1 (lane 2) and TANK2 (lane 4) and probed with EB02508 (mock transfection in first lane). Lane three is empty. Lower panel shows the same ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB
Clonality
Polyclonal
Host
Goat
Conjugate
Unconjugated
Concentration
0.5 mg/ml

Order Details

Tankyrase 1 Antibody Summary

Immunogen
Peptide with sequence RECOMBINANT corresponding to N-Terminus according to NP_003738.2.
Epitope
N Terminal Region
Specificity
Fusion protein containing 120aa amino acids from N Terminal region (according to NP_003738.2)
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
TNKS
Purity
Protein G purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Western Blot 0.5 - 1.5 ug/ml
Application Notes
WB: In transfected HEK293 transiently expressing TANK1 a band of approx. 142 kDa is observed. This band is not observed in the non-transfected HEK293. The calculated molecular size is 142 kDa band according to NP_003738.2.
Publications
Read Publication using NBP1-36994.

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
0.5 mg/ml Tris (pH 7.3) and 0.5% BSA
Preservative
0.02% Sodium Azide
Concentration
0.5 mg/ml
Purity
Protein G purified

Alternate Names for Tankyrase 1 Antibody

  • EC 2.4.2.30
  • PARP5A
  • PARP-5a
  • PARP5APARPL
  • PARPL
  • pART5
  • Poly [ADP-ribose] polymerase 5A
  • TANK1
  • Tankyrase 1
  • Tankyrase I
  • tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
  • tankyrase-1
  • TIN1TANK1
  • TINF1
  • TINF1TNKS-1
  • TNKS
  • TNKS1TRF1-interacting ankyrin-related ADP-ribose polymerase

Background

Tankyrase is a protein with homology to ankyrins as well as to the catalytic domain of poly (adenosine diphosphate-ribose) polymerase (PARP). Tankyrase localizes to telomeres by binding to the telomeric repeat binding factor 1 (TRF1) through its ankyrin repeats. TRF1 is a negative regulator of telomere length maintenance. Tankyrase exhibits PARP activity functioning as acceptors for adenosine diphosphate (ADP)-ribosylation. Since ADP-ribosylation of TRF1 diminishes its ability to bind to telomeric DNA, this suggests that telomere function in human cells is regulated by poly (ADP)-ribosylation. Both the cell cycle and TRF1 may regulate the subcellular localization of tankyrase. During interphase tankyrase co-localizes with TRF1 to telomeres plus nuclear pore complexes whereas during mitosis tankyrase localizes around the pericentriolar matrix of mitotic chromosomes.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Video Protocols

WB Video Protocol

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol TNKS
Entrez
Uniprot