Recombinant Human TANK Protein

Images

 
SDS-Page: TANK Protein [NBC1-22948] - TANK, 13.6 kDa (119 aa), confirmed by MALDI-TOF with a purity of 90% by SDS - PAGE

Product Details

Summary
Reactivity HuSpecies Glossary
Applications PAGE
Concentration
1 mg/ml

Order Details

Recombinant Human TANK Protein Summary

Description
An un-tagged recombinant protein corresponding to the amino acids 1-119 of Human TANK

Source: E.coli

Amino Acid Sequence: MDKNIGEQLN KAYEAFRQAC MDRDSAVKEL QQKTENYEQR IREQQEQLSL QQTIIDKLKS QLLLVNSTQD NNYGCVPLLE DSETRKNNLT LDQPQDKVIS GIAREKLPKV DIASAESSI

Source
E. coli
Protein/Peptide Type
Recombinant Protein
Gene
TANK
Purity
>90%, by SDS-PAGE

Applications/Dilutions

Theoretical MW
13.6 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
20mM Tris-HCl buffer (pH8.0)
Preservative
No Preservative
Concentration
1 mg/ml
Purity
>90%, by SDS-PAGE

Alternate Names for Recombinant Human TANK Protein

  • ITRAF
  • I-TRAF
  • I-TRAFTRAF2
  • TANK
  • TRAF family member-associated NF-kappa-B activator
  • TRAF family member-associated NFKB activator
  • TRAF-interacting protein

Background

TANK, also known as TRAF(tumor necrosis factor receptor-associated Factor)-interacting protein, is found in the cytoplasm and can bind to TRAF1, TRAF2, or TRAF3, thereby proposing that this protein is an inhibitor of TRAF function that regulates TRAF protein activity by sequestering TRAFs in a latent state in the cytoplasm. Overexpression of TANK inhibits TRAF2-mediated NF-Kappa-B activation signaled by CD40 and both TNF receptors and inhibits LMP1-mediated NF-kappa-B activation by blocking the association of TRAF2 with LMP1. Recombinant human TANK protein was expressed in E.coli and purified by using conventional chromatography techniques.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

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Bioinformatics

Gene Symbol TANK
Entrez