TANK Products

Description

The TRAF (tumor necrosis factor receptor-associated factor) family of proteins associate with and transduce signals from members of the tumor necrosis factor receptor superfamily. The protein encoded by this gene is found in the cytoplasm and can bind to TRAF1, TRAF2, or TRAF3, thereby inhibiting TRAF function by sequestering the TRAFs in a latent state in the cytoplasm. For example, the protein encoded by this gene can block TRAF2 binding to LMP1, the Epstein-Barr virus transforming protein, and inhibit LMP1-mediated NF-kappa-B activation. Two transcript variants encoding different isoforms have been found for this gene. Transcript Variant: This variant (1) is the longer transcript and encodes the longer isoform (a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Bioinformatics

Product By Gene ID	10010
Alternate Names	ITRAF I-TRAF I-TRAFTRAF2 TANK TRAF family member-associated NF-kappa-B activator TRAF family member-associated NFKB activator TRAF-interacting protein

Research Areas for TANK

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cancer
Tumor Suppressors