TANK Products

Description

The TRAF (tumor necrosis factor receptor-associated factor) family of proteins associate with and transduce signals from members of the tumor necrosis factor receptor (TNFR) superfamily. TANK/I-TRAF (TRAF family member associated NF-kB activator/TRAF-interacting protein) that was first defined as a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction (reviewed in Bonif 2006). TANK/I-TRAF is thought to inhibit TRAF function by sequestering the TRAFs in the cytoplasm, thereby blocking their recruitment to the TNFR. TANK/I-TRAF has also been shown to bind to other proteins in the NF-kB signaling pathway, including NEMO. However, the role and different functions of TANK/I-TRAF in NF-kB signaling pathways remains to be fully elucidated. Recognizes TANK/I-TRAF, human TANK/I-TRAF is a 425 amino acid protein.

Bioinformatics

Entrez	10010 Human 21353 Mouse 252961 Rat
Uniprot	AAH03388 Human AAH03388.1 Human NM_004180 Human NP_004171 Human NP_597841 Human NP_597841.1 Human
Product By Gene ID	10010
Alternate Names	ITRAF I-TRAFTRAF2 TRAF family member-associated NF-kappa-B activator TRAF family member-associated NFKB activator TRAF-interacting protein

Research Areas for TANK

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cancer
Tumor Suppressors