Syndecan-1/CD138 Antibody (359103) [Alexa Fluor® 750]

Images

 
There are currently no images for Syndecan-1/CD138 Antibody (FAB2780S).

Every product we sell is backed by Novus' 100% Guarantee. If you have used this product, please submit your images and reviews to earn reward points.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow
Clone
359103
Clonality
Monoclonal
Host
Rat
Conjugate
Alexa Fluor 750
Concentration
Please see the vial label for concentration. If unlisted please contact technical services.

Syndecan-1/CD138 Antibody (359103) [Alexa Fluor® 750] Summary

Immunogen
Mouse myeloma cell line NS0-derived recombinant human Syndecan-1/CD138
Gln18-Glu251
Accession # NP_002988
Specificity
Detects human Syndecan-1 in direct ELISAs. In direct ELISAs, this antibody shows approximately 60% cross-reactivity with recombinant mouse (rm) Syndecan‑1 and no cross-reactivity with recombinant human (rh) Syndecan-2, rhSyndecan-3, or rmSyndecan-4.
Isotype
IgG1
Clonality
Monoclonal
Host
Rat
Gene
SDC1
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Flow Cytometry 0.25-1 ug/10^6 cells
Application Notes
Flow Cytometry: Please use 0.25-1 ug of conjugated antibody per 10e6 cells.

Packaging, Storage & Formulations

Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.
Buffer
Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.
Preservative
0.09% Sodium Azide
Concentration
Please see the vial label for concentration. If unlisted please contact technical services.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Syndecan-1/CD138 Antibody (359103) [Alexa Fluor® 750]

  • CD138 antigen
  • CD138
  • SDC
  • SDC1
  • SYND1heparan sulfate proteoglycan fibroblast growth factor receptor
  • syndecan 1
  • syndecan proteoglycan 1
  • syndecan
  • Syndecan1
  • Syndecan-1

Background

Syndecan-1, designated CD138, is a dimeric type I transmembrane (TM) protein that belongs to the syndecan family of Type 1 transmembrane proteins (1, 2). The four syndecan family members are major carriers of heparan sulfate (HS) and chondroitin sulfate glycosaminoglycans (GAGs) that have different expression patterns and extracellular sequences. Syndecan-1 forms weak non-covalent homodimers, or heterodimers with Syndecan-2 or -3, through interactions of the transmembrane domain (3). It is synthesized as a 310 amino acid (aa) precursor with a 17 aa signal sequence, a 234 aa extracellular domain (ECD) that includes three closely-spaced consensus Ser-Gly HS attachment sites near the N-terminus, a 25 aa TM segment, and a 34 aa cytoplasmic region that includes a PDZ binding motif with a tyrosine phosphorylation site. The ECD is variably modified by GAGs, producing molecular weights of 120-200 kDa for native Syndecan-1. Soluble forms are shed via proteolytic cleavage. Human Syndecan-1 ECD shares 65-71% aa identity with the ECD of rat, mouse, canine, equine and bovine Syndecan-1. Syndecan-1 shows highest expression on epithelial cells such as keratinocytes, and terminally differentiated B cells such as plasma cells (4, 5). It aids wound healing in skin, cornea, and heart following myocardial infarction by promoting re-epithelialization, migration, and collagen deposition (4-8). It binds chemokines, creating chemotactic gradients when shed, but also binds and modulates integrins to control the influx of leukocytes (5, 7, 9). The net effect is to allow, but limit, inflammation. In myeloma and other cancers, shedding of Syndecan-1 can facilitate growth, angiogenesis and metastasis (10-12). Growth factors, such as FGFs and HGF, bind GAG chains and use Syndecan-1 as a coreceptor (12, 13). The GAG chains may also be used by a variety of viruses and bacteria for cell adhesion and uptake (4).

  1. Tkachenko, E. et al. (2005) Circ. Res. 96:488.
  2. Mali, M. et al. (1990) J. Biol. Chem. 265:6884.
  3. Dews, I.C. and K.R. MacKenzie (2007) Proc. Natl. Acad. Sci. USA 104:20782.
  4. Fears, C.Y. and A. Woods (2006) Matrix Biol. 25:443.
  5. Stepp, M.A. et al. (2002) J. Cell Sci. 115:4517.
  6. Ojeh, N. et al. (2008) J. Invest. Dermatol. 128:26.
  7. Stepp, M.A. et al. (2007) J. Cell Sci. 120:2851.
  8. Vanhoutte, D. et al. (2007) Circulation 115:475.
  9. Li, Q. et al. (2002) Cell 111:635.
  10. Beauvais, D.M. et al. (2009) J. Exp. Med. 206:691.
  11. Yang, Y. et al. (2007) J. Biol. Chem. 282:13326.
  12. Derksen, P.W.B. et al. (2002) Blood 99:1405.
  13. Su, G. et al. (2007) J. Biol. Chem. 282:14906.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Customers Who Viewed This Item Also Viewed...

AF2918
Species: Hu
Applications: WB, Flow, CyTOF-ready, ICC
AF6585
Species: Mu
Applications: WB, Flow, IHC, CyTOF-ready
NBP1-47386
Species: Hu, Mu, Rb(-)
Applications: WB, ELISA, Flow, ICC/IF, IHC, IHC-P, Flow-IC
NBP2-67309
Species: Hu, Rt
Applications: WB, Flow, ICC/IF, IHC, IHC-P, IP
NBP1-43435
Species: Hu, Mu
Applications: WB, Flow
NB100-77417
Species: Mu
Applications: WB, Flow, ICC/IF, IHC, IHC-Fr, IHC-P, IP, In vivo, CyTOF-ready
NBP2-25250
Species: Hu, Mu
Applications: WB, Simple Western, ICC/IF, IHC, IHC-Fr, IHC-P
AF1182
Species: Hu
Applications: WB, Flow, IHC, IP, CyTOF-ready, ELISA(Cap), ELISA(Det), ELISA(Sta)
AF-386-PB
Species: Hu
Applications: WB, Flow, CyTOF-ready, ICC
NBP1-84550
Species: Hu
Applications: WB, IHC, IHC-P
NB100-524
Species: Hu, Mu
Applications: WB, Flow, ICC/IF, IHC, IHC-Fr, IHC-P, IP, Flow-IC
NBP2-31369
Species: Hu
Applications: WB, IHC, IHC-P
NBP2-25196
Species: Hu, Mu
Applications: WB, Flow, ICC/IF, IHC, In vitro, CyTOF-ready
AF5525
Species: Hu
Applications: WB, IHC
AF2364
Species: Hu
Applications: WB, IHC
NBP1-33197
Species: Hu, Mu
Applications: WB, ELISA, Flow, ICC/IF, IHC, IHC-Fr, IHC-P, IP
NBP1-91258
Species: Hu, Mu, Bv, Ca, Fe
Applications: WB, Simple Western, ICC/IF, IHC, IHC-Fr, IHC-P
NBP1-47396
Species: Hu
Applications: WB, ELISA, IHC, IHC-P
FAB2780S
Species: Hu
Applications: Flow

Publications for Syndecan-1/CD138 Antibody (FAB2780S) (0)

There are no publications for Syndecan-1/CD138 Antibody (FAB2780S).
By submitting your publication information earn gift cards and discounts for future purchases.

Reviews for Syndecan-1/CD138 Antibody (FAB2780S) (0)

There are no reviews for Syndecan-1/CD138 Antibody (FAB2780S). By submitting a review you will receive an Amazon e-Gift Card or Novus Product Discount.
  • Review with no image -- $10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen
  • Review with an image -- $25/€18/£15/$25 CAD/¥150 Yuan/¥2500 Yen
  • 1st to review with an image -- $50/€35/£30/$50 CAD/¥300 Yuan/¥5000 Yen

Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

FAQs for Syndecan-1/CD138 Antibody (FAB2780S) (0)

There are no specific FAQs related to this product. Read our general customer & technical service FAQs.

Secondary Antibodies

 

Isotype Controls

Additional Array Products

Bioinformatics Tool for Syndecan-1/CD138 Antibody (FAB2780S)

Discover related pathways, diseases and genes to Syndecan-1/CD138 Antibody (FAB2780S). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
Visit Tool

Diseases for Syndecan-1/CD138 Antibody (FAB2780S)

Discover more about diseases related to Syndecan-1/CD138 Antibody (FAB2780S).
 

Pathways for Syndecan-1/CD138 Antibody (FAB2780S)

View related products by pathway.

PTMs for Syndecan-1/CD138 Antibody (FAB2780S)

Learn more about PTMs related to Syndecan-1/CD138 Antibody (FAB2780S).

Blogs on Syndecan-1/CD138

There are no specific blogs for Syndecan-1/CD138, but you can read our latest blog posts.

Customers Who Bought This Also Bought

Syndecan-1/CD138
2780-SD-050

Contact Information

Product PDFs

Calculators

Concentration Calculator

The concentration calculator allows you to quickly calculate the volume, mass or concentration of your vial. Simply enter your mass, volume, or concentration values for your reagent and the calculator will determine the rest.

=
÷

Review this Product

Be the first to review our Syndecan-1/CD138 Antibody (359103) [Alexa Fluor® 750] and receive a gift card or discount.

Bioinformatics

Gene Symbol SDC1
Entrez
Uniprot