SWAP70 Antibody

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Western Blot: SWAP70 Antibody [NB100-56430] - Analysis of SWAP-70 in Daudi cell lysate using this antibody.

Product Details

Summary
Reactivity Hu, Mu, Bv, Ca, PmSpecies Glossary
Applications WB
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
0.5 mg/ml

Order Details

SWAP70 Antibody Summary

Immunogen
A portion of amino acids 300-350 of human SWAP-70 was used as the immunogen.
Predicted Species
Mouse (90%), Bovine (95%), Primate (100%), Canine (95%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
SWAP70
Purity
Protein G purified
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Applications/Dilutions

Dilutions
  • Western Blot 1-3 ug/ml

Reactivity Notes

Reacts with Human. Predicted to react with Bovine, Chimpanzee, Dog and Mouse.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS containing 0.2% gelatin
Preservative
0.05% Sodium Azide
Concentration
0.5 mg/ml
Purity
Protein G purified

Alternate Names for SWAP70 Antibody

  • KIAA0640SWAP-70FLJ39540
  • SWAP switching B-cell complex 70kDa subunit
  • SWAP70
  • switch-associated protein 70

Background

SWAP70 is a 585 amino acid regulatory protein belonging to the pleckstrin-like family with a PH domain essential for phosphatidylinositol 3, 4, 5-trisphosphate binding. SWAP70 acts as a link between the recognition of specific switch regions and causation of a DNA break and is involved in both nuclear events and in signaling B-cell activation. As a guanine nucleotide exchange factor (GEF) it transduces signals from tyrosine kinase receptors to RAC, independent of RAS. As a multiple functional signaling protein, and a component of SWAP enzyme complex, it mediates signaling of membrane ruffling by tyrosine kinase growth factor receptors, actin cytoskeleton and cell protrusion. It is widely expressed in most tissues, mature B-cells, including those associated with mucosa-associated tissue and bronchus-associated tissue, monocytes and macrophages.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol SWAP70
Entrez
Uniprot