SUR1 Antibody

Western Blot: SUR1 Antibody [NBP3-12497] - 1:10000 antibody dilution in DiluOBuffer. Apparent MW is 18.5 KDa.

• Reactivity: Hu, Mu, Rt
• Applications: WB, ELISA, IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated

SUR1 Antibody Summary

• Description: Novus Biologicals Rabbit SUR1 Antibody (NBP3-12497) is a polyclonal antibody validated for use in IHC, WB and ELISA. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: Synthetic peptide corresponding to positions 1560-1582.
• Clonality: Polyclonal
• Host: Rabbit
• Gene: ABCC8
• Purity: Affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:10000-1:100000
  • Immunohistochemistry
  • Immunohistochemistry-Frozen 1:200
  • Western Blot 1:500

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: Contains Tris, HCl/glycine buffer (pH 7.4-7.8), 30% glycerol, 0.5% BSA, along with cryo-protective agents, and HEPES (exact storage and stabilization buffer information is proprietary).
• Preservative: 0.02% Sodium Azide
• Purity: Affinity purified

Alternate Names for SUR1 Antibody

• ABC36
• ABCC8
• ATP-binding cassette, sub-family C (CFTR/MRP), member 8
• HHF1Sulfonylurea receptor 1
• HI
• HRINS
• PHHIHRINS
• sulfonylurea receptor (hyperinsulinemia)
• SUR
• SUR1
• SUR1MRP8
• SURATP-binding cassette transporter sub-family C member 8
• TNDM2ATP-binding cassette sub-family C member 8

Background

SUR1 is encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a modulator of ATP-sensitive potassium channels and insulin release. Mutations and deficiencies in this protein have been observed in patients with hyperinsulinemic hypoglycemia of infancy, an autosomal recessive disorder of unregulated and high insulin secretion. Mutations have also been associated with non-insulin-dependent diabetes mellitus type II, an autosomal dominant disease of defective insulin secretion. Alternative splicing of this gene has been observed; however, the transcript variants have not been fully described.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: ABCC8