Sulfatase-2/SULF2 Antibody (2B4) [PE/Cy5.5]

Product Discontinued

Sulfatase-2/SULF2 Antibody (2B4) [PE/Cy5.5] Summary

• Immunogen: Partial recombinant human Sulfatase 2 isoform b [Accession# NP_940998].
• Localization: Endoplasmic reticulum
• Specificity: Does not recognize human or mouse Sulfatase 1 or other family members.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: SULF2
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • CyTOF-ready
  • ELISA
  • Flow Cytometry
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Immunoprecipitation
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined. For optimal results using our Tandem dyes, please avoid prolonged exposure to light or extreme temperature fluctuations. These can lead to irreversible degradation or decoupling. When staining intracellular targets, specific attention to the fixation and permeabilization steps in your flow protocol may be required. Please contact our technical support team at technical@novusbio.com if you have any questions.

Reactivity Notes

Human and mouse.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark. Do not freeze.
• Buffer: PBS
• Preservative: 0.05% Sodium Azide
• Purity: Protein G purified

Alternate Names for Sulfatase-2/SULF2 Antibody (2B4) [PE/Cy5.5]

• DKFZp313E091
• EC 3.1.6
• EC 3.1.6.-
• EC 3.1.6.14
• extracellular sulfatase Sulf-2
• FLJ44488
• FLJ90554
• hSulf-2
• KIAA1247HSULF-2
• MGC126411
• SULF2
• SULF-2
• sulfatase 2
• Sulfatase2
• Sulfatase-2

Background

Heparan sulfate proteoglycans (HSPGs) act as coreceptors for numerous heparin-binding growth factors and cytokines and are involved in cell signaling. Heparan sulfate 6-O-endosulfatases, such as Sulfatase 2, selectively remove 6-O-sulfate groups from heparan sulfate. This activity modulates the effects of heparan sulfate by altering binding sites for signaling molecules (Dai et al., 2005 [PubMed 16192265]) [supplied by OMIM].

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: SULF2