STAT4 Antibody (513710) [Alexa Fluor® 405]

• Reactivity: Hu, Mu
• Applications: WB
• Clone: 513710
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 405

STAT4 Antibody (513710) [Alexa Fluor® 405] Summary

• Immunogen: E. coli-derived recombinant human STAT4
  Leu83-Lys162
  Accession # Q14765
• Specificity: Detects endogenous human STAT4 in Western blots.
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for STAT4 Antibody (513710) [Alexa Fluor® 405]

• signal transducer and activator of transcription 4
• SLEB11
• STAT4

Background

Signal transduction and activator of transcription 4 (STAT4) is a 86 kDa member of the Jak/STAT signal transduction pathway. Human STAT4 is 748 amino acids (aa) in length. STAT4 mediates cytokine signaling by acting as a signal transducer in the cytoplasm and, upon phosphorylation, homo- or heterodimerizes with other STAT proteins, which then translocate to the nucleus and activate transcription of specific genes. STAT4 contains a SH2 domain (aa 569‑664) and a Jak1 phophorylation site at Y693. STAT4 is involved in mediating IL‑12 response in lymphocytes and regulating T helper cell differentiation, and STAT4 variants are found in patients with systemic lupus erythematosus.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.