Stabilin-1 Antibody (840449) [Alexa Fluor® 750]

• Reactivity: Hu
• Applications: IHC
• Clone: 840449
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 750

Stabilin-1 Antibody (840449) [Alexa Fluor® 750] Summary

• Immunogen: E. coli-derived recombinant human Stabilin-1
  Gly2208-Val2305
  Accession # Q9NY15
• Specificity: Detects human Stabilin-1 in direct ELISAs.
• Source: N/A
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is provided under an agreement between Life Technologies Corporation and R&D Systems, Inc, and the manufacture, use, sale or import of this product is subject to one or more US patents and corresponding non-US equivalents, owned by Life Technologies Corporation and its affiliates. The purchase of this product conveys to the buyer the non-transferable right to use the purchased amount of the product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components (1) in manufacturing; (2) to provide a service, information, or data to an unaffiliated third party for payment; (3) for therapeutic, diagnostic or prophylactic purposes; (4) to resell, sell, or otherwise transfer this product or its components to any third party, or for any other commercial purpose. Life Technologies Corporation will not assert a claim against the buyer of the infringement of the above patents based on the manufacture, use or sale of a commercial product developed in research by the buyer in which this product or its components was employed, provided that neither this product nor any of its components was used in the manufacture of such product. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, Cell Analysis Business Unit, Business Development, 29851 Willow Creek Road, Eugene, OR 97402, Tel: (541) 465-8300. Fax: (541) 335-0354.

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Stabilin-1 Antibody (840449) [Alexa Fluor® 750]

• CLEVER-1
• fasciclin egf-like, laminin-type egf-like, and link domain-containing scavengerreceptor-1
• Fasciclin, EGF-like, laminin-type EGF-like and link domain-containing scavengerreceptor 1
• FEEL1
• FEEL-1
• FEEL-1MS-1 antigen
• FELE-1
• FEX1
• KIAA0246common lymphatic endothelial and vascular endothelial receptor-1
• MS-1 Antigen
• STAB1
• STAB-1
• stabilin 1
• Stabilin1
• Stabilin-1

Background

Stabilin-1, also known as FEEL-1 (fasciclin, EGF-like, laminin type EGF-like, and link domain containing scavenger receptor-1) and CLEVER-1 (common lymphatic endothelial and vascular endothelial receptor-1), was originally identified as the MS-1 antigen. It is a type I transmembrane multi-domain protein with a large extracellular domain that contains 7 fasciclin domains, multiple EGF-like and laminin type EGF-like domains, and a link domain. The short cytoplasmic tail interacts with cargo adaptors that link cargo into the clathrin-coated pits (CGAs). Stabilin-1 is expressed by tissue macrophages and sinusoidal endothelial cells, which are scavenging cells. Stabilin-1 is involved in intracellular trafficking pathways and binds multiple ligands, including acetylated LDL, SPARC, AGE, and SI-CLP. An alternatively spliced, soluble, 803 amino acid (aa) Stabilin-1 that diverges after aa 746 has been identified. Within the region used as immunogen, human Stabilin-1 shares 83% and 84% amino acid sequence homology with mouse and canine Stabilin-1, respectively.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Uniprot:
  • Q9NY15()