SREBP2 Antibody (1D2) [DyLight 550]

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Product Details

Summary
Reactivity Hu, ChSpecies Glossary
Applications WB, ELISA, ICC/IF
Clone
1D2
Clonality
Monoclonal
Host
Mouse
Conjugate
DyLight 550

SREBP2 Antibody (1D2) [DyLight 550] Summary

Immunogen
Human SREBP2 protein (amino acids 48-403). [UniProt# Q12772]
Localization
Endoplasmic reticulum and Golgi apparatus membranes,cytoplasmic vesicle. Mature/processed form localized to nucleus.
Specificity
Recognizes the precursor and mature forms of human SREBP2.
Isotype
IgG1 Kappa
Clonality
Monoclonal
Host
Mouse
Gene
SREBF2
Purity
Protein G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot
  • ELISA
  • Immunocytochemistry/Immunofluorescence

Reactivity Notes

Chicken was reported in PMIDs 15333705 and 11907029.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein G purified

Notes

Dylight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for SREBP2 Antibody (1D2) [DyLight 550]

  • bHLhd2
  • bHLHd2sterol regulatory element-binding protein 2
  • Class D basic helix-loop-helix protein 2
  • SREBF2
  • SREBP2
  • SREBP2SREBP-2
  • sterol regulatory element binding transcription factor 2
  • Sterol regulatory element-binding transcription factor 2

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol
ICC/IF Video Protocol

FAQs for SREBP2 Antibody (NBP1-54446R) (0)

There are no specific FAQs related to this product. Read our general customer & technical service FAQs.

Secondary Antibodies

 

Isotype Controls

Other Available Formats

Alexa Fluor 350 NBP1-54446AF350
Alexa Fluor 405 NBP1-54446AF405
Alexa Fluor 488 NBP1-54446AF488
Alexa Fluor 532 NBP1-54446AF532
Alexa Fluor 594 NBP1-54446AF594
Alexa Fluor 647 NBP1-54446AF647
Alexa Fluor 700 NBP1-54446AF700
Alexa Fluor 750 NBP1-54446AF750
Biotin NBP1-54446B
DyLight 350 NBP1-54446UV
DyLight 405 NBP1-54446V
DyLight 488 NBP1-54446G
DyLight 550 NBP1-54446R
DyLight 594 NBP1-54446DL594
DyLight 650 NBP1-54446C
DyLight 680 NBP1-54446FR
DyLight 755 NBP1-54446IR
HRP NBP1-54446H
Janelia Fluor 549 NBP1-54446JF549
Janelia Fluor 646 NBP1-54446JF646

Additional SREBP2 Products

Bioinformatics Tool for SREBP2 Antibody (NBP1-54446R)

Discover related pathways, diseases and genes to SREBP2 Antibody (NBP1-54446R). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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Diseases for SREBP2 Antibody (NBP1-54446R)

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Pathways for SREBP2 Antibody (NBP1-54446R)

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PTMs for SREBP2 Antibody (NBP1-54446R)

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Blogs on SREBP2.

SREBP2 - regulating cholesterol homeostasis and lipid metabolism
Sterol regulatory element-binding proteins (SREBP) are important transcription factors regulating the synthesis and uptake of lipids including cholesterol. This essential role in lipid metabolism makes investigations into the functions SREBPs im...  Read full blog post.

SREBP: Gatekeeper of Cholesterol Homeostasis
SREBP1 (sterol-regulatory-element-binding protein 2) is a basic-helix-loop-helix-leucine zipper (bHLH-ZIP) transcription factor. It regulates sterol and cholesterol homeostasis by controlling enzymes involved in cholesterol synthesis and uptake, e.g....  Read full blog post.

SREBPs: Global Regulator of Lipid Metabolism
Sterol regulatory element binding proteins (SREBPs) are indirectly required for cholesterol biosynthesis and for uptake and fatty acid biosynthesis. There are three known SREBP isoforms, SREBP1a, 1c and SREBP2; these have different roles in lipid synt...  Read full blog post.

SREBP2: From Cholesterol Homeostasis to Cancer Invasion
Sterol-regulatory-element-binding protein 2 (SREBP2) is a transcription factor that regulates cholesterol homeostasis by controlling enzymes involved in cholesterol synthesis and uptake, e.g. HMG-CoA. Along with another transcription factor LXR, SREBP...  Read full blog post.

ABCA1 Expression is Down-Regulated by SREBP microRNA
The ABCA1 (ATP-binding cassette transporter-A1) gene encodes a transmembrane protein, which plays a major role in phospholipid homeostasis by regulating cholesterol efflux from the cell. ABCA1 antibody studies have shown ABCA1 expression is up/down re...  Read full blog post.

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Bioinformatics

Gene Symbol SREBF2