SPTLC1 Antibody [Alexa Fluor™ Plus 555]

• Reactivity: Hu
• Applications: WB, ELISA, IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Alexa Fluor Plus 555

SPTLC1 Antibody [Alexa Fluor™ Plus 555] Summary

• Immunogen: SPTLC1 antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human SPTLC1. The immunogen is located within amino acids 380 - 430 of SPTLC1. Amino Acid Squence: HLQLEESTGSREQDVRL
• Specificity: At least two isoforms of SPTLC1 are known to exist; this antibody will detect only isoform a. SPTLC1 antibody is predicted to not cross-react with SPT2.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: SPTLC1
• Purity: Peptide affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Reactivity Notes

Immunogen displays the following percentage of sequence identity for non-tested species: Mouse: (88%)

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Peptide affinity purified

Notes

This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for SPTLC1 Antibody [Alexa Fluor™ Plus 555]

• EC 2.3.1.50
• hereditary sensory neuropathy, type 1
• HSAN1
• LBC1
• LCB 1
• LCB1
• LCB1HSAN
• Long chain base biosynthesis protein 1
• MGC14645
• serine C-palmitoyltransferase
• serine palmitoyltransferase 1
• serine palmitoyltransferase, long chain base subunit 1
• Serine-palmitoyl-CoA transferase 1
• SPT 1
• SPT1
• SPT1HSN1
• SPTI
• SPTLC1

Background

Serine palmitoyltransferase, which consists of two different subunits, is the key enzyme in sphingolipid biosynthesis. It converts L-serine and palmitoyl-CoA to 3-oxosphinganine with pyridoxal 5'-phosphate as a cofactor. The product of this gene is the long chain base subunit 1 of serine palmitoyltransferase. Mutations in this gene were identified in patients with hereditary sensory neuropathy type 1. Alternatively spliced variants encoding different isoforms have been identified. (provided by RefSeq)

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: SPTLC1