SPRY2 Antibody [FITC]

• Reactivity: Hu, Mu
• Applications: WB
• Clonality: Polyclonal
• Host: Goat
• Conjugate: FITC

SPRY2 Antibody [FITC] Summary

• Immunogen: E. coli-derived recombinant human SPRY2
  Met1-Ala175
  Accession # O43597
• Specificity: Detects human and mouse SPRY2 in Western blots.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: SPRY2
• Purity: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: PBS
• Preservative: 0.05% Sodium Azide
• Purity: Antigen Affinity-purified

Alternate Names for SPRY2 Antibody [FITC]

• hSPRY2
• MGC23039
• protein sprouty homolog 2
• sprouty (Drosophila) homolog 2
• sprouty 2
• sprouty homolog 2 (Drosophila)
• SPRY2
• spry-2

Background

Sprouty 2 encodes a protein belonging to the sprouty family. The encoded protein contains a carboxyl-terminal cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is required for growth factor stimulated translocation of the protein to membrane ruffles. In primary dermal endothelial cells this gene is transiently upregulated in response to fibroblast growth factor two. This protein is indirectly involved in the non-cell autonomous inhibitory effect on fibroblast growth factor two signaling. The protein interacts with Cas-Br-M (murine) ectropic retroviral transforming sequence, and can function as a bimodal regulator of epidermal growth factor receptor/mitogen-activated protein kinase signaling. This protein may play a role in alveoli branching during lung development as shown by a similar mouse protein.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: SPRY2