SP110 Antibody


Western Blot: SP110 Antibody [NBP1-77316] - Hela cell lysate with SP110 antibody at (A) 0.5, (B) 1, and (C) 2 ug/ml.
Immunohistochemistry-Paraffin: SP110 Antibody [NBP1-77316] - Human brain tissue using SP110 antibody at 2.5 ug/ml.
Immunofluorescence: SP110 Antibody [NBP1-77316] - SP110 in Human Brain cells with IPR1 antibody at 50 ug/mL.

Product Details

Reactivity Hu, Mu, RtSpecies Glossary
Applications WB, ELISA, IHC, IHC-P, IF
1 mg/ml

Order Details

SP110 Antibody Summary

Antibody was raised against a 15 amino acid peptide near the carboxy terminus of the human IPR1.
Immunogen affinity purified
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Test in a species/application not listed above to receive a full credit towards a future purchase.

Packaging, Storage & Formulations

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
0.02% Sodium Azide
1 mg/ml
Immunogen affinity purified


Reactivity Notes

Human, Mouse, Rat

Alternate Names for SP110 Antibody

  • FLJ22835
  • IFI41
  • IFI75
  • interferon-induced protein 41, 30kD
  • Interferon-induced protein 41/75
  • interferon-induced protein 75, 52kD
  • IPR1
  • phosphoprotein 41
  • phosphoprotein 75
  • SP110 nuclear body protein
  • Speckled 110 kDa
  • Transcriptional coactivator Sp110
  • VODI


Susceptibility to tuberculosis (TB) in mice has recently been attributed to the IPR1 gene. IPR1 is a member of the SP100/SP140 family of nuclear body proteins and encodes a leukocyte-specific nuclear body component. The protein can function as an activator of gene transcription and may serve as a nuclear hormone receptor coactivator. Alternative splicing has been observed for this gene and three transcript variants, encoding distinct isoforms, have been identified. SP110 is the closest homolog of the IPR1 protein in humans. The IPR1/Sp110 gene product might play a role in integrating signals generated by intracellular pathogens with mechanisms controlling innate immunity, cell death, and pathogenesis. IPR1/Sp110 is up-regulated after infection with M. tuberculosis and required by Anaplasma phagocytophilum for infection of human promyelocytic cells. Defects in Sp110 are a cause of severely impaired resistance to infection by M. tuberculosis.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol

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Secondary Antibodies


Isotype Controls

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Contact Information

Product PDFs


Gene Symbol SP110

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