SP110 Antibody - BSA Free

Western Blot: SP110 Antibody [NBP1-77316] - Hela cell lysate with SP110 antibody at (A) 0.5, (B) 1, and (C) 2 ug/ml.

Immunocytochemistry/ Immunofluorescence: SP110 Antibody - BSA Free [NBP1-77316] - Immunofluorescence of SP110 in Human Brain cells with SP110 antibody at 50 u/mL.

Immunohistochemistry: SP110 Antibody - BSA Free [NBP1-77316] - Immunohistochemical staining of human brain tissue using SP110 antibody at 2.5 ug/mL.

• Reactivity: Hu, Mu, Rt
• Applications: WB, ELISA, ICC/IF, IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free
• Concentration: 1 mg/ml

SP110 Antibody - BSA Free Summary

• Description: Novus Biologicals Rabbit SP110 Antibody - BSA Free (NBP1-77316) is a polyclonal antibody validated for use in IHC, WB, ELISA and ICC/IF. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: Antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of the human IPR1. The immunogen is located within amino acids 470 - 520 of IPR1. Amino Acid Squence: CIRNEDGTWLTPNEF
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: SP110
• Purity: Peptide affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:100-1:2000
  • Immunocytochemistry/ Immunofluorescence 20 ug/ml
  • Immunohistochemistry 2.5 ug/ml
  • Immunohistochemistry-Paraffin 2.5 ug/ml
  • Western Blot 0.5-2 ug/ml
• Control Peptide:

  SP110 Peptide (NBP1-77316PEP)

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.02% Sodium Azide
• Concentration: 1 mg/ml
• Purity: Peptide affinity purified

Alternate Names for SP110 Antibody - BSA Free

• FLJ22835
• IFI41
• IFI75
• interferon-induced protein 41, 30kD
• Interferon-induced protein 41/75
• interferon-induced protein 75, 52kD
• IPR1
• phosphoprotein 41
• phosphoprotein 75
• SP110 nuclear body protein
• Speckled 110 kDa
• Transcriptional coactivator Sp110
• VODI

Background

Susceptibility to tuberculosis (TB) in mice has recently been attributed to the IPR1 gene. IPR1 is a member of the SP100/SP140 family of nuclear body proteins and encodes a leukocyte-specific nuclear body component. The protein can function as an activator of gene transcription and may serve as a nuclear hormone receptor coactivator. Alternative splicing has been observed for this gene and three transcript variants, encoding distinct isoforms, have been identified. SP110 is the closest homolog of the IPR1 protein in humans. The IPR1/Sp110 gene product might play a role in integrating signals generated by intracellular pathogens with mechanisms controlling innate immunity, cell death, and pathogenesis. IPR1/Sp110 is up-regulated after infection with M. tuberculosis and required by Anaplasma phagocytophilum for infection of human promyelocytic cells. Defects in Sp110 are a cause of severely impaired resistance to infection by M. tuberculosis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: SP110
• Uniprot:
  • NP_004501(Human)